O-Benzyl-N-[(R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propyl]-hydroxylamine

Base Information

• Chemical Name: O-Benzyl-N-[(R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propyl]-hydroxylamine
• CAS No.: 188909-36-6
• Molecular Formula: C₃₄H₄₇NO₄Si
• Molecular Weight: 561.837
• Mol file: 188909-36-6.mol

Synonyms:

Chemical Property of O-Benzyl-N-[(R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propyl]-hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-Benzyl-N-[(R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propyl]-hydroxylamine

There total 4 articles about O-Benzyl-N-[(R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propyl]-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-O-t-butyldiphenylsilyl-3,4-O-isopropylidene-L-erythrulose (147107-70-8) → O-Benzyl-N-[(R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propyl]-hydroxylamine (188909-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / pyridine / methanol / 0.5 h / Heating

2: diethyl ether / 1 h / -78 °C

With pyridine; In methanol; diethyl ether;

DOI:10.1016/S0957-4166(98)00145-1

Reference yield:

tert.-butyl lithium (594-19-4) + 2-(tert-Butyl-diphenyl-silanyloxy)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanone O-benzyl-oxime (188909-23-1) → O-Benzyl-N-[(R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propyl]-hydroxylamine (188909-36-6) + O-Benzyl-N-[(S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propyl]-hydroxylamine

Guidance literature:

In diethyl ether; at -78 ℃; for 1h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4039(97)00165-2

Reference yield:

O-benzylhydoxylamine hydrochloride (2687-43-6) → O-Benzyl-N-[(R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propyl]-hydroxylamine (188909-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / pyridine / methanol / 0.5 h / Heating

2: diethyl ether / 1 h / -78 °C

With pyridine; In methanol; diethyl ether;

DOI:10.1016/S0957-4166(98)00145-1

upstream raw materials:

tert.-butyl lithium

2-(tert-Butyl-diphenyl-silanyloxy)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanone O-benzyl-oxime

O-benzylhydoxylamine hydrochloride

1-O-t-butyldiphenylsilyl-3,4-O-isopropylidene-L-erythrulose