N-butyl, N-methyl-9-(3'-benzyloxy-17'-oxo-1',3',5'(10')-estratriene-15'(α,β)-yl)-nonamide

Base Information

Chemical Name:N-butyl, N-methyl-9-(3'-benzyloxy-17'-oxo-1',3',5'(10')-estratriene-15'(α,β)-yl)-nonamide
CAS No.:138743-08-5
Molecular Formula:C₃₉H₅₅NO₃
Molecular Weight:585.871
Hs Code.:

Synonyms:

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Chemical Property of N-butyl, N-methyl-9-(3'-benzyloxy-17'-oxo-1',3',5'(10')-estratriene-15'(α,β)-yl)-nonamide

Chemical Property:

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Technology Process of N-butyl, N-methyl-9-(3'-benzyloxy-17'-oxo-1',3',5'(10')-estratriene-15'(α,β)-yl)-nonamide

There total 9 articles about N-butyl, N-methyl-9-(3'-benzyloxy-17'-oxo-1',3',5'(10')-estratriene-15'(α,β)-yl)-nonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 858-98-0
3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one

: 138743-08-5,138743-20-1
N-butyl, N-methyl-9-(3'-benzyloxy-17'-oxo-1',3',5'(10')-estratriene-15'(α,β)-yl)-nonamide

Guidance literature:: Multi-step reaction with 9 steps

1: p-TSA

2: pyridine*HBr₃

3: t-BuOK / dimethylsulfoxide

4: p-TSA / acetone; H₂O

6: K₂CO₃ / methanol / 1 h / Ambient temperature

7: 90 percent / p-toluenesulfonic acid / methanol / Ambient temperature; 1.5 to 4 h

8: 8N chromic acid solution / acetone / 1 h / 0 °C

9: 1) tributylamine, isobutyl chloroformate / 1) CH₂Cl₂, -10 deg C, 40 min, 2) CH₂Cl₂, 1.5 h

With pyridinium perbromide hydrobromide; tributyl-amine; potassium tert-butylate; chromic acid; potassium carbonate; toluene-4-sulfonic acid; isobutyl chloroformate; In methanol; water; dimethyl sulfoxide; acetone;
DOI:10.1016/S0040-4020(01)81933-5

Reference yield:

: 138743-03-0
(14α)-3-benzyloxy-1,3,5(10),15-estratetraen-17-one

: 138743-08-5,138743-20-1
N-butyl, N-methyl-9-(3'-benzyloxy-17'-oxo-1',3',5'(10')-estratriene-15'(α,β)-yl)-nonamide

Guidance literature:: Multi-step reaction with 5 steps

2: K₂CO₃ / methanol / 1 h / Ambient temperature

3: 90 percent / p-toluenesulfonic acid / methanol / Ambient temperature; 1.5 to 4 h

4: 8N chromic acid solution / acetone / 1 h / 0 °C

5: 1) tributylamine, isobutyl chloroformate / 1) CH₂Cl₂, -10 deg C, 40 min, 2) CH₂Cl₂, 1.5 h

With tributyl-amine; chromic acid; potassium carbonate; toluene-4-sulfonic acid; isobutyl chloroformate; In methanol; acetone;
DOI:10.1016/S0040-4020(01)81933-5

Reference yield:

: 162784-26-1
17,17-ethylenedioxy-3-benzyloxy-estra-1,3,5 ⁽¹⁰⁾-trien-17-one

: 138743-08-5,138743-20-1
N-butyl, N-methyl-9-(3'-benzyloxy-17'-oxo-1',3',5'(10')-estratriene-15'(α,β)-yl)-nonamide

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine*HBr₃

2: t-BuOK / dimethylsulfoxide

3: p-TSA / acetone; H₂O

5: K₂CO₃ / methanol / 1 h / Ambient temperature

6: 90 percent / p-toluenesulfonic acid / methanol / Ambient temperature; 1.5 to 4 h

7: 8N chromic acid solution / acetone / 1 h / 0 °C

8: 1) tributylamine, isobutyl chloroformate / 1) CH₂Cl₂, -10 deg C, 40 min, 2) CH₂Cl₂, 1.5 h

With pyridinium perbromide hydrobromide; tributyl-amine; potassium tert-butylate; chromic acid; potassium carbonate; toluene-4-sulfonic acid; isobutyl chloroformate; In methanol; water; dimethyl sulfoxide; acetone;
DOI:10.1016/S0040-4020(01)81933-5