162784-26-1

Basic information

• Product Name: 3-O-Benzyl Estrone Monoethylene Ketal
• Synonyms: 3-O-Benzyl Estrone Monoethylene Ketal;3-(Benzyloxy)-estra-1,3,5(10)-trien-17-one Cyclic 1,2-Ethanediyl Acetal;3-(PhenylMethoxy)-estra-1,3,5(10)-trien-17-one Cyclic 1,2-Ethanediyl Acetal
• CAS NO: 162784-26-1
• Molecular Formula: C₂₇H₃₂O₃
• Molecular Weight: 404.54118
• Product Categories: Intermediates & Fine Chemicals. Steroids;Pharmaceuticals;Pharmaceuticals, Intermediates & Fine Chemicals. Steroids
• Mol File: 162784-26-1.mol

Chemical Properties

• Boiling Point: 549.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• Solubility: Chloroform,
• CAS DataBase Reference: 3-O-Benzyl Estrone Monoethylene Ketal(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-Benzyl Estrone Monoethylene Ketal(162784-26-1)
• EPA Substance Registry System: 3-O-Benzyl Estrone Monoethylene Ketal(162784-26-1)

Safety Data

• Hazardous Substances Data: 162784-26-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Estetrol intermediate.

Upstream product

• 858-98-0 3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one 
• 107-21-1 ethylene glycol 
• 100-44-7 benzyl chloride 
• 900-83-4 (8R,9S,13S,14S)-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2′-[1,3]dioxolan]-3-ol 

Downstream Products

• 138743-04-1 3-benzyloxy-15(α,β)-<9'-<(tetrahydro-2''H-pyran-2''-yl)oxy>-1'-nonanyl>-1,3,5(10)-estratriene-17-one 
• 138743-08-5 N-butyl, N-methyl-9-(3'-benzyloxy-17'-oxo-1',3',5'(10')-estratriene-15'(α,β)-yl)-nonamide 
• 138743-09-6 N-butyl, N-methyl-9-(3'-benzyloxy-17'β-hydroxy-1',3',5'(10')-estratriene-15'(α,β)-yl)-nonamide 
• 138743-06-3 3-benzyloxy-15(α,β)-(9'-hydroxy-1'-nonanyl)-1,3,5(10)-estratriene-17-one 
• 534572-67-3 3-benzyloxy-17,17-ethylenedioxyestra-1,3,5⁽¹⁰⁾,15-tetraene 
• 138743-03-0 (14α)-3-benzyloxy-1,3,5(10),15-estratetraen-17-one 
• 690996-27-1 16-bromo-17,17-ethylenedioxy-3-benzyloxy-estra-1,3,5 ⁽¹⁰⁾-trien-17-one 

Relevant articles and documents

SYNTHESIS OF ESTETROL VIA ESTRONE DERIVED STEROIDS

A process is provided for the making of estetrol starting from a 3-A-oxy-estra 1,3,5(10),15-tetraen-17-one, wherein A is an C1-C5 alkyl group, preferably a methyl group, or a C7 - C12 benzylic group, preferably a benzyl group. This process is particularly suitable to industry.

SYNTHESIS OF 17β-ESTRADIOL DERIVATIVES WITH N-BUTYL, N-METHYL ALKYLAMIDE SIDE CHAIN AT POSITION 15

New derivatives of 17-β-estradiol with N-butyl, N-methyl alkylamide side chains of three different lengths at position 15 have been synthesized from estrone.Compounds 5 and 6 having a shorter alkylamide chain were obtained in eleven steps by introduction