C₁₀H₁₅BrN₄

Base Information

• Chemical Name: C₁₀H₁₅BrN₄
• CAS No.: 1538120-10-3
• Molecular Formula: C₁₀H₁₅BrN₄
• Molecular Weight: 271.16
• Mol file: 1538120-10-3.mol

Synonyms:

Chemical Property of C₁₀H₁₅BrN₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₁₅BrN₄

There total 2 articles about C₁₀H₁₅BrN₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-chloro-N-cyclohexylpyrimidin-4-amine (864655-05-0) → C10H15BrN4 (1538120-10-3)

Guidance literature:

With ammonium hydroxide; In isopropyl alcohol; at 120 ℃; Inert atmosphere;

DOI:10.1021/jm500118j

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → C10H15BrN4 (1538120-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Inert atmosphere; Reflux

2: ammonium hydroxide / isopropyl alcohol / 120 °C / Inert atmosphere

With ammonium hydroxide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; isopropyl alcohol;

DOI:10.1021/jm500118j

Reference yield:

C10H15BrN4 (1538120-10-3) + (3-chloropyridin-4-yl)boronic acid (458532-98-4) → C15H18ClN5 (1588959-23-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; at 120 - 150 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/jm500118j

upstream raw materials:

cyclohexylamine

5-bromo-2-chloro-N-cyclohexylpyrimidin-4-amine

Downstream raw materials:

C₁₅H₁₈ClN₅

(9-cyclohexyl-9H-pyrido[4′,3′,4,5]pyrrolo[2,3-d]pyrimidin-2-yl)-(5-piperazin-1-yl-pyridin-2-yl)amine

Refernces