1-(4-Methoxy-2-methylphenyl)vinyl chloride

Base Information

• Chemical Name: 1-(4-Methoxy-2-methylphenyl)vinyl chloride
• CAS No.: 74346-23-9
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.65
• Mol file: 74346-23-9.mol

Synonyms:

Chemical Property of 1-(4-Methoxy-2-methylphenyl)vinyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Methoxy-2-methylphenyl)vinyl chloride

There total 2 articles about 1-(4-Methoxy-2-methylphenyl)vinyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-methoxy-2-methylphenyl)ethanone (24826-74-2) → 1-(4-Methoxy-2-methylphenyl)vinyl chloride (74346-23-9)

Guidance literature:

With phosphorus pentachloride; at 15 ℃;

DOI:10.1021/jo01307a032

Reference yield:

4'-hydroxy-2'methylacetophenone (875-59-2) → 1-(4-Methoxy-2-methylphenyl)vinyl chloride (74346-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 N NaOH / 0.5 h / 40 - 50 °C

2: phosphorus pentachloride / 15 °C

With sodium hydroxide; phosphorus pentachloride;

DOI:10.1021/jo01307a032

Reference yield:

1-(4-Methoxy-2-methylphenyl)vinyl chloride (74346-23-9) → 1-(4-Methoxy-2-methylphenyl)vinyl bromide (74346-24-0)

Guidance literature:

Multi-step reaction with 2 steps

2: hydrogen bromide

With hydrogen bromide;

DOI:10.1021/jo01307a032

upstream raw materials:

1-(4-methoxy-2-methylphenyl)ethanone

4'-hydroxy-2'methylacetophenone

Downstream raw materials:

1-ethynyl-4-methoxy-2-methylbenzene

1-(4-Methoxy-2-methylphenyl)vinyl bromide

1-(4-Methoxy-2-methylphenyl)vinyl tosylate