875-59-2

Basic information

• Product Name: 4'-HYDROXY-2'-METHYLACETOPHENONE
• Synonyms: 4''-HYDROXY-2''-METHYLACETOPHENONE 97%;2-Methyl-4-hydroxybenzaldehyde;1-(4-hydroxy-2-Methylphenyl)ethan-1-one;4'-HYDROXY-2'-METHYLACETOPHENONE;4-HYDROXY-2-METHYLACETOPHENONE;4-ACETYL-3-METHYLPHENOL;2-METHYL-4-HYDROXYACETOPHENONE;1-(4-Hydroxy-2-methylphenyl)ethanone
• CAS NO: 875-59-2
• Molecular Formula: C₉H₁₀O₂
• Molecular Weight: 150.17
• EINECS: 212-874-2
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);C9;Carbonyl Compounds;Ketones
• Mol File: 875-59-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 129-131 °C(lit.)
• Boiling Point: 313 °C(lit.)
• Flash Point: 127.9 °C
• Appearance: Off-white to beige to tan/Powder or Crystals
• Density: 1.059 g/mL at 25 °C(lit.)
• Refractive Index: 1.5369 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 8.28±0.18(Predicted)
• CAS DataBase Reference: 4'-HYDROXY-2'-METHYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-HYDROXY-2'-METHYLACETOPHENONE(875-59-2)
• EPA Substance Registry System: 4'-HYDROXY-2'-METHYLACETOPHENONE(875-59-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• Hazardous Substances Data: 875-59-2(Hazardous Substances Data)

Usage

Chemical Properties

off-white to beige crystalline powder

Uses

4''-Hydroxy-2''-methylacetophenone has been used in the preparation of morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity.

Definition

ChEBI: A member of the class of acetophenones that is acetophenone substituted by a hydroxy group at position 4 and a methyl group at position 2 respectively.

Preparation

Preparation by dealkylation of 4-hydroxy-2-methyl-5-iso-propylacetophenone with aluminium chloride in chlorobenzene at 50° (80%).

Upstream product

• 7647-01-0 hydrogenchloride 
• 6921-64-8 4'-hydroxy-2'-methylacetophenone 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 7446-70-0 aluminium trichloride 
• 122-46-3 3-acetoxytoluene 
• 7664-39-3 hydrogen fluoride 
• 7550-45-0 titanium tetrachloride 
• 98-95-3 nitrobenzene 
• 107-06-2 1,2-dichloro-ethane 
• 108-39-4 3-methyl-phenol 
• 64-19-7 acetic acid 
• 101816-75-5 1-(4-hydroxy-2-methyl-phenyl)-ethanone oxime 
• 72698-81-8 1-(4-acetoxy-2-methyl-phenyl)-ethanone 
• 75-15-0 carbon disulfide 

Downstream Products

• 166953-77-1 methyl 4-acetyl-3-methylphenoxyacetate 
• 75258-84-3 (E)-2-benzylidene-5-methoxy-2,3-dihydro-1H-inden-1-one 
• 73124-45-5 methyl-3 ethyl-4 cyclohexanone cis 
• 29121-47-9 2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-2-methyl-phenyl]-acetamide 
• 29121-53-7 2-(4-Hydroxy-2-methyl-phenyl)-acetamide 
• 34681-84-0 acetic acid-(4-ethyl-3-methyl-phenyl ester) 
• 75112-71-9 1-(4-methoxy-2-methyl-phenyl)-ethanone oxime 
• 103096-81-7 bis-(5-acetyl-2-hydroxy-4-methyl-3-nitro-phenyl)-sulfide 
• 103096-87-3 bis-(5-acetyl-3-bromo-2-hydroxy-4-methyl-phenyl)-sulfide 
• 578-39-2 4-hydroxy-2-methylbenzoic acid 
• 74331-69-4 1-ethynyl-4-methoxy-2-methylbenzene 
• 74331-92-3 1-(4-Methoxy-2-methylphenyl)vinyl tosylate 
• 74346-24-0 1-(4-Methoxy-2-methylphenyl)vinyl bromide 
• 74346-23-9 1-(4-Methoxy-2-methylphenyl)vinyl chloride 

Relevant articles and documents

Catalytic wet air oxidation of m-cresol over a surface-modified sewage sludge-derived carbonaceous catalyst

Sewage sludge-derived carbonaceous materials (SW) treated with different kinds of acids were used as catalysts for catalytic wet air oxidation (CWAO) of m-cresol. The SW catalysts were characterized by XRF, XRD, FTIR, XPS and TPD-MS. The results showed that SW treated with HNO3 (HNO3-SW) exhibited the best catalytic activity. When the initial concentration of m-cresol was 5000 mg L-1, the conversion of m-cresol reached 99.0% with HNO3-SW after 90 min at 160 °C and 0.66 MPa oxygen. Continuous experiments were carried out for 8 d to investigate the durability and catalytic performance of HNO3-SW in CWAO reaction. Some correlation was observed between the conversion of m-cresol and the content of carboxyl groups, indicating that the carboxyl group might play a key role in determining the catalytic activity of SW catalysts in CWAO reaction. Based on the intermediate products identified by GC-MS, HPLC-MS, IC and HRMS analyses, the oxidation pathways of m-cresol in CWAO were proposed.

The phase change storage element and its manufacturing method

Disclosed are a phase change RAM device and a method for fabricating a phase change RAM device, which can efficiently lower intensity of current required for changing a phase of a phase change layer. The method includes the steps of providing a semiconductor substrate formed with an insulating interlayer including a tungsten plug, forming a first oxide layer on the semiconductor substrate, forming a pad-type bottom electrode, which makes contact with the tungsten plug, in the first oxide layer, forming a second oxide layer on the first oxide layer including the bottom electrode, and forming a porous polystyrene pattern on the second oxide layer such that a predetermined portion of the second oxide layer corresponding to a center portion of the bottom electrode is covered with the porous polystyrene pattern.

Tf2O-mediated direct and regiospecific para-acylation of phenols with carboxylic acids

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