5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide

Base Information

Chemical Name:5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide
CAS No.:370105-89-8
Molecular Formula:C₂₄H₁₈ClN₇O₅S₂
Molecular Weight:584.036
Hs Code.:

5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide

Synonyms:

Suppliers and Price of 5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide

There total 5 articles about 5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 370105-86-5
4-[4-chloro-5-(2-methoxy-phenoxy)-6-(5-methyl-pyridine-2-sulfonylamino)-pyrimidin-2-yl]-N-hydroxy-pyridine-2-carboxamidine

: 370105-89-8
5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃;
DOI:10.1016/S0960-894X(02)01084-3

Reference yield:

: C₆H₇N₂O₂S^(1-)*K⁽¹⁺⁾

: 370105-89-8
5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: Huenig's Base / dimethylsulfoxide / 20 °C

2: NaOMe / 24 h / 45 °C

3: NH₂OH*HCl / 0.25 h / 45 °C

4: DBU / acetonitrile / 20 °C

With hydroxylamine hydrochloride; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0960-894X(02)01084-3

Reference yield:

: 285135-68-4
4-[4,6-dichloro-5-(2-methoxy-phenoxy)-pyrimidine-2-yl]-pyridine-2-carbonitrile

: 370105-89-8
5-methyl-pyridine-2-sulfonic acid {6-chloro-5-(2-methoxy-phenoxy)-2-[2-(5-thioxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: Huenig's Base / dimethylsulfoxide / 20 °C

2: NaOMe / 24 h / 45 °C

3: NH₂OH*HCl / 0.25 h / 45 °C

4: DBU / acetonitrile / 20 °C

With hydroxylamine hydrochloride; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0960-894X(02)01084-3