N-[(E)-(4-methoxyphenyl)methylideneamino]-1,3-benzodioxole-5-carboxamide

Base Information

Chemical Name:N-[(E)-(4-methoxyphenyl)methylideneamino]-1,3-benzodioxole-5-carboxamide
CAS No.:270575-94-5
Molecular Formula:C₁₆H₁₄N₂O₄
Molecular Weight:298.298
Hs Code.:
DSSTox Substance ID:DTXSID401325558
ChEMBL ID:CHEMBL3212846
Mol file:270575-94-5.mol

Synonyms:270575-94-5;N'-[(1E)-(4-methoxyphenyl)methylidene]-2H-1,3-benzodioxole-5-carbohydrazide;N-[(E)-(4-methoxyphenyl)methylideneamino]-1,3-benzodioxole-5-carboxamide;N'-[(E)-(4-methoxyphenyl)methylidene]-1,3-benzodioxole-5-carbohydrazide;MLS001195548;CHEMBL3212846;DTXSID401325558;AKOS001049244;SMR000550295;AB00727678-01;8W-0859;SR-01000106434;SR-01000106434-1;Z49725581;N'-[(E)-(4-METHOXYPHENYL)METHYLIDENE]-2H-1,3-BENZODIOXOLE-5-CARBOHYDRAZIDE

Suppliers and Price of N-[(E)-(4-methoxyphenyl)methylideneamino]-1,3-benzodioxole-5-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
N'-[(E)-(4-METHOXYPHENYL)METHYLIDENE]-1,3-BENZODIOXOLE-5-CARBOHYDRAZIDE 95.00%
5MG
$ 687.35

American Custom Chemicals Corporation
N'-[(E)-(4-METHOXYPHENYL)METHYLIDENE]-1,3-BENZODIOXOLE-5-CARBOHYDRAZIDE 95.00%
10MG
$ 679.14

American Custom Chemicals Corporation
N'-[(E)-(4-METHOXYPHENYL)METHYLIDENE]-1,3-BENZODIOXOLE-5-CARBOHYDRAZIDE 95.00%
1MG
$ 647.61

Total 2 raw suppliers

Chemical Property of N-[(E)-(4-methoxyphenyl)methylideneamino]-1,3-benzodioxole-5-carboxamide

Chemical Property:

PKA:11.74±0.20(Predicted)
Density:1.29±0.1 g/cm3(Predicted)
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:298.09535693
Heavy Atom Count:22
Complexity:407

Purity/Quality:

97% ^*data from raw suppliers

N'-[(E)-(4-METHOXYPHENYL)METHYLIDENE]-1,3-BENZODIOXOLE-5-CARBOHYDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C=NNC(=O)C2=CC3=C(C=C2)OCO3
Isomeric SMILES:COC1=CC=C(C=C1)/C=N/NC(=O)C2=CC3=C(C=C2)OCO3

Technology Process of N-[(E)-(4-methoxyphenyl)methylideneamino]-1,3-benzodioxole-5-carboxamide

There total 3 articles about N-[(E)-(4-methoxyphenyl)methylideneamino]-1,3-benzodioxole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 22026-39-7
benzo[d][1,3]dioxole-5-carbohydrazide

: 123-11-5
4-methoxy-benzaldehyde

: 270575-94-5
Benzo[1,3]dioxole-5-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Guidance literature:: With hydrogenchloride; In ethanol; at 20 ℃; for 0.5h;
DOI:10.1016/S0223-5234(00)00120-3

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 270575-94-5
Benzo[1,3]dioxole-5-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / I₂; KOH / 1.5 h / 0 °C

2: 70 percent / 80 percent N₂H₄*H₂O / ethanol / 3.5 h / Heating

3: 70 percent / conc. HCl / ethanol / 0.5 h / 20 °C

With hydrogenchloride; potassium hydroxide; iodine; hydrazine hydrate; In ethanol; 1: Oxidation / 2: Substitution / 3: Condensation;
DOI:10.1016/S0223-5234(00)00120-3

Reference yield:

: 326-56-7
methyl 3,4-methylenedioxybenzoate

: 270575-94-5
Benzo[1,3]dioxole-5-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / 80 percent N₂H₄*H₂O / ethanol / 3.5 h / Heating

2: 70 percent / conc. HCl / ethanol / 0.5 h / 20 °C

With hydrogenchloride; hydrazine hydrate; In ethanol; 1: Substitution / 2: Condensation;
DOI:10.1016/S0223-5234(00)00120-3