Ethyl 2-(4-methoxyphenyl)-5-methyl-3-[(4-nitrophenyl)-1-piperidinylmethyl]-4-oxazolidinecarboxylate

Base Information

Chemical Name:Ethyl 2-(4-methoxyphenyl)-5-methyl-3-[(4-nitrophenyl)-1-piperidinylmethyl]-4-oxazolidinecarboxylate
CAS No.:78979-65-4
Molecular Formula:C₂₆H₃₃N₃O₆
Molecular Weight:483.565
Hs Code.:
DSSTox Substance ID:DTXSID501114247

Synonyms:DTXSID501114247;78979-65-4;Ethyl 2-(4-methoxyphenyl)-5-methyl-3-[(4-nitrophenyl)-1-piperidinylmethyl]-4-oxazolidinecarboxylate

Suppliers and Price of Ethyl 2-(4-methoxyphenyl)-5-methyl-3-[(4-nitrophenyl)-1-piperidinylmethyl]-4-oxazolidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-(4-methoxyphenyl)-5-methyl-3-[(4-nitrophenyl)-1-piperidinylmethyl]-4-oxazolidinecarboxylate

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:483.23693578
Heavy Atom Count:35
Complexity:696

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1C(OC(N1C(C2=CC=C(C=C2)[N+](=O)[O-])N3CCCCC3)C4=CC=C(C=C4)OC)C

Technology Process of Ethyl 2-(4-methoxyphenyl)-5-methyl-3-[(4-nitrophenyl)-1-piperidinylmethyl]-4-oxazolidinecarboxylate

There total 3 articles about Ethyl 2-(4-methoxyphenyl)-5-methyl-3-[(4-nitrophenyl)-1-piperidinylmethyl]-4-oxazolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 110-89-4
piperidine

: 555-16-8
4-nitrobenzaldehdye

: 78979-42-7
(4S,5R)-2-(4-Methoxy-phenyl)-5-methyl-oxazolidine-4-carboxylic acid ethyl ester

: 78979-65-4
(4S,5R)-2-(4-Methoxy-phenyl)-5-methyl-3-[(4-nitro-phenyl)-piperidin-1-yl-methyl]-oxazolidine-4-carboxylic acid ethyl ester

Guidance literature:: In ethanol; for 6h; Heating;
DOI:10.1246/bcsj.54.1844

Reference yield:

: 23926-51-4
(2S,3R)-threonine ethyl ester

: 78979-65-4
(4S,5R)-2-(4-Methoxy-phenyl)-5-methyl-3-[(4-nitro-phenyl)-piperidin-1-yl-methyl]-oxazolidine-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86.7 percent / 2 h / 80 - 90 °C

2: 72 percent / ethanol / 6 h / Heating

In ethanol;
DOI:10.1246/bcsj.54.1844

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 78979-65-4
(4S,5R)-2-(4-Methoxy-phenyl)-5-methyl-3-[(4-nitro-phenyl)-piperidin-1-yl-methyl]-oxazolidine-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86.7 percent / 2 h / 80 - 90 °C

2: 72 percent / ethanol / 6 h / Heating

In ethanol;
DOI:10.1246/bcsj.54.1844