HO-Leu-N-Me-Val-D-Leu-D-Phe-3,3-diphenyl-D-Ala-NH₂

Base Information

• Chemical Name: HO-Leu-N-Me-Val-D-Leu-D-Phe-3,3-diphenyl-D-Ala-NH₂
• CAS No.: 1610523-60-8
• Molecular Formula: C₄₂H₅₇N₅O₆
• Molecular Weight: 727.944
• Mol file: 1610523-60-8.mol

Synonyms:

Chemical Property of HO-Leu-N-Me-Val-D-Leu-D-Phe-3,3-diphenyl-D-Ala-NH₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of HO-Leu-N-Me-Val-D-Leu-D-Phe-3,3-diphenyl-D-Ala-NH₂

There total 1 articles about HO-Leu-N-Me-Val-D-Leu-D-Phe-3,3-diphenyl-D-Ala-NH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Fmoc-Leu-preloaded Wang resin, deprotected + N-(9-fluorenylmethoxycarbonyl)-D-leucine (35661-60-0,126727-03-5,114360-54-2) + Fmoc-D-Phe-OH (86123-10-6) + Fmoc-N-methylvaline (103478-58-6,84000-11-3) + Fmoc-3,3-diphenyl-D-alanine (189937-46-0,201484-50-6) → HO-Leu-N-Me-Val-D-Leu-D-Phe-3,3-diphenyl-D-Ala-NH2 (1610523-60-8)

Guidance literature:

Fmoc-Leu-preloaded Wang resin, deprotected; Fmoc-N-methylvaline; With benzotriazol-1-ol; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; for 3h; 2-chlorotrityl-leucine resin

With piperidine; In N,N-dimethyl-formamide; isopropyl alcohol; for 0.433333h; 2-chlorotrityl-leucine resin

N-(9-fluorenylmethoxycarbonyl)-D-leucine; Fmoc-D-Phe-OH; Fmoc-3,3-diphenyl-D-alanine; Further stages;

DOI:10.1021/ml500114p

Reference yield: 39.0%

HO-Leu-N-Me-Val-D-Leu-D-Phe-3,3-diphenyl-D-Ala-NH2 (1610523-60-8) → cyclo-Leu-N-Me-Val-D-Leu-D-Phe-3,3-diphenyl-D-Ala (1610523-48-2)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In dichloromethane;

DOI:10.1021/ml500114p

upstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-D-leucine

Fmoc-D-Phe-OH

Fmoc-N-methylvaline

Fmoc-3,3-diphenyl-D-alanine

Downstream raw materials:

cyclo-Leu-N-Me-Val-D-Leu-D-Phe-3,3-diphenyl-D-Ala

Refernces