(E)-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]-imidazol-2(3H)-ylidene)nicotinamide

Base Information

Chemical Name:(E)-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]-imidazol-2(3H)-ylidene)nicotinamide
CAS No.:1357920-45-6
Molecular Formula:C₃₂H₄₄N₆O₃
Molecular Weight:560.74
Hs Code.:

(E)-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]-imidazol-2(3H)-ylidene)nicotinamide

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Chemical Property of (E)-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]-imidazol-2(3H)-ylidene)nicotinamide

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Technology Process of (E)-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]-imidazol-2(3H)-ylidene)nicotinamide

There total 4 articles about (E)-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]-imidazol-2(3H)-ylidene)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.2%

: 59-67-6
nicotinic acid

: 1357920-41-2
(1s,4s)-4-(2-amino-6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-N-isopropylcyclohexanecarboxamide

: 1357920-45-6,1388225-82-8
(E)-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]-imidazol-2(3H)-ylidene)nicotinamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 50 ℃;
DOI:10.1021/jm3005866

Reference yield:

: 22990-34-7
2-(piperidin-4-yl)propan-2-ol

: 1357920-45-6,1388225-82-8
(E)-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]-imidazol-2(3H)-ylidene)nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 0.75 h / 5 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 80 °C

3.1: 5%-palladium/activated carbon; ammonium formate / ethanol; water / 2.25 h / 5 °C / Inert atmosphere

4.1: 1,4-dioxane / 0.08 h / 100 °C

4.2: 1 h / 20 - 60 °C

5.1: hydrogenchloride / water / 24 h / 50 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 50 °C

With hydrogenchloride; 5%-palladium/activated carbon; ammonium formate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3005866

Reference yield:

: 160538-51-2
3-fluoro-4-nitro-benzaldehyde

: 1357920-45-6,1388225-82-8
(E)-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]-imidazol-2(3H)-ylidene)nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 0.75 h / 5 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 80 °C

3.1: 5%-palladium/activated carbon; ammonium formate / ethanol; water / 2.25 h / 5 °C / Inert atmosphere

4.1: 1,4-dioxane / 0.08 h / 100 °C

4.2: 1 h / 20 - 60 °C

5.1: hydrogenchloride / water / 24 h / 50 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 50 °C

With hydrogenchloride; 5%-palladium/activated carbon; ammonium formate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3005866