Technology Process of (3bR,4aS)-6-[3-(2-Methoxy-5-pyrimidinyl)-2(E)-propenoyl]-2-methyl-8-oxo-1,4,4a,5,6,8-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-3-carboxylic acid methyl ester
There total 6 articles about (3bR,4aS)-6-[3-(2-Methoxy-5-pyrimidinyl)-2(E)-propenoyl]-2-methyl-8-oxo-1,4,4a,5,6,8-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-3-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: TFA, trifluoroacetic anhydride, N-iodosuccinimide / 11 h / 80 °C
2: 88 percent / Pd(OAc)2, K2CO3, n-Bu4NCl / dimethylformamide / 1 h / 80 °C
3: 96 percent / 4N aq. KOH / methanol / 2 h / 50 °C
4: 90 percent / Et3N, 2-chloro-1-methylpyridinium chloride / CH2Cl2 / 2 h / 50 °C
5: 1.) NaH / 1.) DMF, -20 deg C, 260 min, 2.) DMF, 80 min
With
palladium diacetate; potassium hydroxide; N-iodo-succinimide; tetrabutyl-ammonium chloride; sodium hydride; 1-methyl-2-chloropyridinium chloride; potassium carbonate; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980559y
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 88 percent / Pd(OAc)2, K2CO3, n-Bu4NCl / dimethylformamide / 1 h / 80 °C
2: 96 percent / 4N aq. KOH / methanol / 2 h / 50 °C
3: 90 percent / Et3N, 2-chloro-1-methylpyridinium chloride / CH2Cl2 / 2 h / 50 °C
4: 1.) NaH / 1.) DMF, -20 deg C, 260 min, 2.) DMF, 80 min
With
palladium diacetate; potassium hydroxide; tetrabutyl-ammonium chloride; sodium hydride; 1-methyl-2-chloropyridinium chloride; potassium carbonate; triethylamine;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980559y
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 96 percent / 4N aq. KOH / methanol / 2 h / 50 °C
2: 90 percent / Et3N, 2-chloro-1-methylpyridinium chloride / CH2Cl2 / 2 h / 50 °C
3: 1.) NaH / 1.) DMF, -20 deg C, 260 min, 2.) DMF, 80 min
With
potassium hydroxide; sodium hydride; 1-methyl-2-chloropyridinium chloride; triethylamine;
In
methanol; dichloromethane;
DOI:10.1021/jm980559y
