Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester
• CAS No.: 109049-53-8
• Molecular Formula: C₆₁H₅₁Cl₂N₆O₁₁P
• Molecular Weight: 1145.99

Synonyms:

Chemical Property of Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester

There total 8 articles about Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-methoxyphenyldiazomethane (23304-25-8) → Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester (109049-53-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 29 percent / SnCl₂*H₂O / dimethylformamide / 2 h / 45 °C

2: pyridine / 1 h

3: N-methylimidazole

With pyridine; 1-methyl-1H-imidazole; tin(ll) chloride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)82051-2

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester (109049-53-8)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrazine / diethyl ether / 0 - 10 °C

2: HgO, KOH / methanol / 1 h

3: 29 percent / SnCl₂*H₂O / dimethylformamide / 2 h / 45 °C

4: pyridine / 1 h

5: N-methylimidazole

With pyridine; 1-methyl-1H-imidazole; potassium hydroxide; tin(ll) chloride; mercury(II) oxide; hydrazine; In methanol; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)82051-2

Reference yield:

(4-methoxybenzylidene)-hydrazine (5953-85-5,214466-47-4) → Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(4-methoxy-benzyloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester (109049-53-8)

Guidance literature:

Multi-step reaction with 4 steps

1: HgO, KOH / methanol / 1 h

2: 29 percent / SnCl₂*H₂O / dimethylformamide / 2 h / 45 °C

3: pyridine / 1 h

4: N-methylimidazole

With pyridine; 1-methyl-1H-imidazole; potassium hydroxide; tin(ll) chloride; mercury(II) oxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)82051-2

upstream raw materials:

Phosphorochloridic acid 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester

5'-O-dimethoxytrityl-2'-O-(4-methoxybenzyl)-N⁶-benzoyl adenosine

p-methoxyphenyldiazomethane

4,4'-dimethoxytrityl chloride

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