1-[(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
CAS No.:199528-79-5
Molecular Formula:C₃₅H₃₃N₃O₇S₂
Molecular Weight:671.795
Hs Code.:

1-[(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 10 articles about 1-[(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 199528-75-1
1-[(2R,3S,4S,5R)-3-Hydroxy-5-hydroxymethyl-4-(pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 199528-79-5
1-[(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: With pyridine; dmap; for 10h;
DOI:10.1080/07328319708006225

Reference yield:

: 75096-60-5
1,2-O-isopropylidene-5-O-(4-toluoyl)-D-xylofuranose

: 199528-79-5
1-[(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 8 steps

1: DMAP / CH₂Cl₂ / Ambient temperature

2: dimethylformamide / 5 h / 80 °C

3: HCOOH / 1 h / 50 °C

4: pyridine

5: 2.) TMSTf / 2.) MeCN

6: MeONa / methanol

8: 91 percent / pyridine, DMAP / 10 h

With pyridine; dmap; formic acid; TMSTf; sodium methylate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/07328319708006225

Reference yield:

: 75096-61-6
1,2-O-isopropylidene-5-O-(4-methylbenzoyl)-3-O-trifluoromethanesulfonyl-α-D-xylofuranose

: 199528-79-5
1-[(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1: dimethylformamide / 5 h / 80 °C

2: HCOOH / 1 h / 50 °C

3: pyridine

4: 2.) TMSTf / 2.) MeCN

5: MeONa / methanol

7: 91 percent / pyridine, DMAP / 10 h

With pyridine; dmap; formic acid; TMSTf; sodium methylate; In methanol; N,N-dimethyl-formamide;
DOI:10.1080/07328319708006225