(E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate

Base Information

Chemical Name:(E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate
CAS No.:1416550-05-4
Molecular Formula:C₄₈H₅₂BrN₁₁O₇
Molecular Weight:974.914
Hs Code.:

(E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate

Synonyms:

Suppliers and Price of (E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate

There total 6 articles about (E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1416550-04-3
(E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-iodophenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate

: 173208-24-7
2-bromo-N-(prop-2-ynyl)acetamide

: 1416550-05-4
(E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; for 0.5h;
DOI:10.1039/c2cc37826d

Reference yield:

: 1160707-35-6
1-[2-hydroxy-2-(4-hydroxyphenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide

: 1416550-05-4
(E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium iodide; potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 20 °C

2.1: N-chloro-succinimide; chloro-trimethyl-silane / dichloromethane / 1.5 h

2.2: 1.5 h / 20 °C

3.1: triethylamine / dichloromethane / 4 h

4.1: triethylamine / dichloromethane / 20 - 35 °C

5.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 0.5 h

With N-chloro-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro-trimethyl-silane; potassium tert-butylate; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2cc37826d

Reference yield:

: 201858-51-7
p-methyl red

: 1416550-05-4
(E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

2: hydrogenchloride / 2 h / 20 °C

3: triethylamine / dichloromethane / 20 - 35 °C

4: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 0.5 h

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2cc37826d