1-[2-hydroxy-2-(4-hydroxyphenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide

Base Information

• Chemical Name: 1-[2-hydroxy-2-(4-hydroxyphenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide
• CAS No.: 1160707-35-6
• Molecular Formula: C₂₀H₂₁IN₂O₄
• Molecular Weight: 480.302
• Mol file: 1160707-35-6.mol

Synonyms:1-[2-hydroxy-2-(4-hydroxyphenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide

Chemical Property of 1-[2-hydroxy-2-(4-hydroxyphenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-hydroxy-2-(4-hydroxyphenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide

There total 2 articles about 1-[2-hydroxy-2-(4-hydroxyphenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-(4-iodophenyl)piperidine-4-carboxamide hydrochloride (1416549-80-8) + 4-hydroxymandelic acid (1198-84-1) → 1-[2-hydroxy-2-(4-hydroxyphenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide (1160707-35-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1039/c2cc37826d

Reference yield: 55.0%

C24H25IN2O6 (1160707-34-5) → 1-[2-hydroxy-2-(4-hydroxyphenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide (1160707-35-6)

Guidance literature:

C₂₄H₂₅IN₂O₆; With water; sodium hydroxide; In 1,4-dioxane; for 0.0833333h; Cooling with ice;

With hydrogenchloride; In 1,4-dioxane; water; pH=2;

Reference yield: 78.0%

chloro-methylsulfanyl-methane (2373-51-5) + 1-[2-hydroxy-2-(4-hydroxyphenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide (1160707-35-6) → 1-[2-hydroxy-2-(4-(methylthiomethoxy)phenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide (1160707-36-7)

Guidance literature:

1-[2-hydroxy-2-(4-hydroxyphenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide; With sodium iodide; In N,N-dimethyl-formamide;

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; Cooling with ice;

chloro-methylsulfanyl-methane; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

upstream raw materials:

C₂₄H₂₅IN₂O₆

N-(4-iodophenyl)piperidine-4-carboxamide hydrochloride

4-hydroxymandelic acid

Downstream raw materials:

1-[2-hydroxy-2-(4-(methylthiomethoxy)phenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide

(E)-1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl 4-(4-((4-(dimethylamino)phenyl)diazenyl)benzamido)cyclohexylcarbamate

1-(4-(azidomethoxy)phenyl)-2-(4-(4-iodophenylcarbamoyl)piperidin-1-yl)-2-oxoethyl (3,4,5-trihydroxy-6-(isopropylthio)tetrahydro-2H-pyran-2-yl)methylcarbonate

1-(4-(azidomethoxy)phenyl)-2-(4-(4-(3-(2-bromoacetamido)prop-1-ynyl)phenylcarbamoyl)piperidin-1-yl)-2-oxoethyl (3,4,5-trihydroxy-6-(isopropylthio)tetrahydro-2H-pyran-2-yl)methylcarbonate