tert-butyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate

Base Information

• Chemical Name: tert-butyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate
• CAS No.: 129460-15-7
• Molecular Formula: C₃₀H₄₀N₂O₆
• Molecular Weight: 524.657
• Mol file: 129460-15-7.mol

Synonyms:

Chemical Property of tert-butyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate

There total 3 articles about tert-butyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

di-tert-butyl dicarbonate (24424-99-5) + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) → tert-butyl N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysinate (129460-15-7)

Guidance literature:

With dmap; at 20 ℃;

DOI:10.1039/c8ra01387j

Reference yield: 67.0%

Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) + tert-butyl alcohol (75-65-0) → tert-butyl N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysinate (129460-15-7)

Guidance literature:

With dmap; di-tert-butyl dicarbonate; at 35 ℃; for 22h; Inert atmosphere;

DOI:10.1039/c0ob00832j

Reference yield:

tert-Butyl 2,2,2-trichloroacetimidate (98946-18-0) → tert-butyl N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysinate (129460-15-7)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; Cyclohexane-d12; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2019.111960

upstream raw materials:

Fmoc-Lys(tert-butoxycarbonyl)

tert-butyl alcohol

di-tert-butyl dicarbonate

tert-Butyl 2,2,2-trichloroacetimidate