2-(4-METHOXY-BENZYL)-BENZOOXAZOLE

Base Information

• Chemical Name: 2-(4-METHOXY-BENZYL)-BENZOOXAZOLE
• CAS No.: 101554-05-6
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.274
• Hs Code.: 2934999090
• Mol file: 101554-05-6.mol

Synonyms:2-(4-methoxybenzyl)benzo[d]oxazole;2-(p-methoxybenzyl)benzoxazole;2-(4-methoxybenzyl)benzoxazole;2-(4-methoxybenzyl)-1,3-benzoxazole;Benzoxazole,2-[(4-methoxyphenyl)methyl];

Chemical Property of 2-(4-METHOXY-BENZYL)-BENZOOXAZOLE

Chemical Property:

• PSA: 35.26000
• LogP: 3.42720
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Methoxybenzyl)benzo[d]oxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-METHOXY-BENZYL)-BENZOOXAZOLE

There total 15 articles about 2-(4-METHOXY-BENZYL)-BENZOOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzoxazole (273-53-0,29791-96-6) + p-methoxybenzyl chloride (824-94-2) → 2-(4-methoxybenzyl)-1,3-benzoxazole (101554-05-6)

Guidance literature:

With NHC-Pd(II)-Im; lithium tert-butoxide; In toluene; at 130 ℃; for 3h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tet.2015.07.030

Reference yield: 88.0%

2-amino-phenol (95-55-6) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 2-(4-methoxybenzyl)-1,3-benzoxazole (101554-05-6)

Guidance literature:

With N-methylcyclohexylamine; sulfur; at 80 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.7b01775

Reference yield: 88.0%

4-Methoxystyrene (637-69-4,24936-44-5) + 2-amino-phenol (95-55-6) → 2-(4-methoxybenzyl)-1,3-benzoxazole (101554-05-6)

Guidance literature:

With N-methylcyclohexylamine; sulfur; at 110 ℃; for 36h; Schlenk technique;

DOI:10.1021/acs.joc.1c01357

upstream raw materials:

4-Methoxyphenylacetic acid

2-amino-phenol

α-(2-benzoxazolyl)-4-methoxybenzyl alcohol

benzoxazole