(S)-1-Benzyl-3-broMo-piperidine

Base Information

• Chemical Name: (S)-1-Benzyl-3-broMo-piperidine
• CAS No.: 283589-04-8
• Molecular Formula: C₁₂H₁₆BrN
• Molecular Weight: 254.17
• Mol file: 283589-04-8.mol

Synonyms:

Chemical Property of (S)-1-Benzyl-3-broMo-piperidine

Chemical Property:

• Boiling Point: 300.6±35.0 °C(Predicted)
• PKA: 7.97±0.10(Predicted)
• Density: 1.336±0.06 g/cm3(Predicted)

Purity/Quality:

(S)-1-Benzyl-3-bromopiperidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-Benzyl-3-broMo-piperidine

There total 4 articles about (S)-1-Benzyl-3-broMo-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-azabicyclo[3.1.0]hexane (285-76-7) + benzyl bromide (100-39-0) → 1-benzyl-3-bromopiperidine (774490-79-8,1353997-04-2,283589-04-8)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1248/cpb.57.1142

Reference yield: 80.0%

(S)-N-benzylprolinol (53912-80-4) → (S)-1-Benzyl-3-bromo-piperidine (1353997-04-2,283589-04-8)

Guidance literature:

With sulfurous dibromide; N,N-dimethyl-formamide; In cyclohexane; at 20 ℃; for 8h;

DOI:10.1016/S0040-4039(00)00330-0

Reference yield: 67.0%

N-benzylpent-4-en-1-amine (54436-58-7) → 1-benzyl-3-bromopiperidine (774490-79-8,1353997-04-2,283589-04-8)

Guidance literature:

With copper(ll) bromide; In acetonitrile; at 20 ℃; for 6h; regioselective reaction;

DOI:10.1002/adsc.201301125

upstream raw materials:

(S)-N-benzylprolinol

1-azabicyclo[3.1.0]hexane

benzyl bromide

N-benzylpent-4-en-1-amine

Refernces

• 1、 Li, Wei,Liu, Gong-Qing,Cui, Bin,Zhang, Li,Li, Ting-Ting,Li, Lin,Duan, Lili,Li, Yue-Ming. "Transition metal-free iodine-promoted haloamination of unfunctionalized olefins". . p. 13509 - 13513. Retrieved 2014/04/03.
• 2、 Nagle, Advait S.,Salvatore, Ralph N.,Chong, Byong-Don,Woon Jung, Kyung. "Efficient synthesis of β-amino bromides". . p. 3011 - 3014. Retrieved 2007/10/03.