3-methyl-5-(2-vinylanilino)pentan-2-one

Base Information

Chemical Name:3-methyl-5-(2-vinylanilino)pentan-2-one
CAS No.:1453542-28-3
Molecular Formula:C₁₄H₁₉NO
Molecular Weight:217.311
Hs Code.:

Synonyms:

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Chemical Property of 3-methyl-5-(2-vinylanilino)pentan-2-one

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Technology Process of 3-methyl-5-(2-vinylanilino)pentan-2-one

There total 11 articles about 3-methyl-5-(2-vinylanilino)pentan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1453542-18-1
5-methyl-4-(2-vinylphenyl)-4-azabicyclo[3.1.0]hexane

: 1453542-28-3
3-methyl-5-(2-vinylanilino)pentan-2-one

Guidance literature:: With acetic acid; at 115 ℃; for 0.25h; under 3000.3 Torr; Temperature; Time; Reagent/catalyst; Solvent; Microwave irradiation;
DOI:10.1002/chem.201300871

Reference yield:

: 614-76-6
N-acetyl-2-bromoaniline

: 1453542-28-3
3-methyl-5-(2-vinylanilino)pentan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 10 h / 80 °C / Inert atmosphere

2.1: titanium(IV) isopropylate; cyclopentylmagnesium chloride; lithium chloride / tetrahydrofuran; diethyl ether / 1.23 h / 0 - 25 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

2.3: 1 h / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.05 h / -70 °C / Inert atmosphere

3.2: 0.5 h / -70 °C / Inert atmosphere

4.1: triethylamine; phosphorus pentoxide / dichloromethane / 3 h / 20 °C / Inert atmosphere

5.1: acetic acid / 0.25 h / 115 °C / 3000.3 Torr / Microwave irradiation

With titanium(IV) isopropylate; phosphorus pentoxide; tert.-butyl lithium; tetra(n-butyl)ammonium hydrogensulfate; cyclopentylmagnesium chloride; acetic acid; triethylamine; lithium chloride; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; pentane; 2.1: |Kulinkovich-De Meijere Reaction;
DOI:10.1002/chem.201300871

Reference yield:

: 615-36-1
2-bromoaniline

: 1453542-28-3
3-methyl-5-(2-vinylanilino)pentan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 0.5 h / 80 °C

2.1: potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 10 h / 80 °C / Inert atmosphere

3.1: titanium(IV) isopropylate; cyclopentylmagnesium chloride; lithium chloride / tetrahydrofuran; diethyl ether / 1.23 h / 0 - 25 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

3.3: 1 h / Inert atmosphere

4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.05 h / -70 °C / Inert atmosphere

4.2: 0.5 h / -70 °C / Inert atmosphere

5.1: triethylamine; phosphorus pentoxide / dichloromethane / 3 h / 20 °C / Inert atmosphere

6.1: acetic acid / 0.25 h / 115 °C / 3000.3 Torr / Microwave irradiation

With titanium(IV) isopropylate; phosphorus pentoxide; tert.-butyl lithium; tetra(n-butyl)ammonium hydrogensulfate; cyclopentylmagnesium chloride; acetic acid; triethylamine; lithium chloride; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; pentane; 3.1: |Kulinkovich-De Meijere Reaction;
DOI:10.1002/chem.201300871