3-cyano-6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo-[4.4.0]decan-5-yl]ethyl]-2-oxo-1,2-dihydropyridine

Base Information

Chemical Name:3-cyano-6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo-[4.4.0]decan-5-yl]ethyl]-2-oxo-1,2-dihydropyridine
CAS No.:1403989-60-5
Molecular Formula:C₃₁H₃₅N₃O₈
Molecular Weight:577.634
Hs Code.:

3-cyano-6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo-[4.4.0]decan-5-yl]ethyl]-2-oxo-1,2-dihydropyridine

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Chemical Property of 3-cyano-6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo-[4.4.0]decan-5-yl]ethyl]-2-oxo-1,2-dihydropyridine

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Technology Process of 3-cyano-6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo-[4.4.0]decan-5-yl]ethyl]-2-oxo-1,2-dihydropyridine

There total 6 articles about 3-cyano-6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo-[4.4.0]decan-5-yl]ethyl]-2-oxo-1,2-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1403989-48-9
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne

: 107-91-5
cyanoacetic acid amide

: 1403989-60-5
3-cyano-6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo-[4.4.0]decan-5-yl]ethyl]-2-oxo-1,2-dihydropyridine

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.5560/ZNB.2012-0108

Reference yield:

: 50-70-4
D-sorbitol

: 1403989-60-5
3-cyano-6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo-[4.4.0]decan-5-yl]ethyl]-2-oxo-1,2-dihydropyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / 20 - 70 °C

2.1: sodium periodate / 1,4-dioxane; water / 48 h / 20 °C

3.1: zinc / toluene; N,N-dimethyl-formamide; diethyl ether / 20 - 35 °C

4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 3 h / 20 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / -40 - 20 °C

5.2: 168 h / 20 °C / Inert atmosphere

6.1: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With sodium periodate; n-butyllithium; sodium hydride; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; water; N,N-dimethyl-formamide; toluene; paraffin oil; 3.1: |Barbier Coupling Reaction;
DOI:10.5560/ZNB.2012-0108

Reference yield:

: 143573-33-5
(1S,3S,5S,6R,8R)-3,8-Di(4-methoxyhenyl)-2,4,7,9-tetraoxabicyclo<4.4.0>decane-5-carboxaldehyde

: 1403989-60-5
3-cyano-6-dimethylamino-4-[(2R)-2-methoxy-2-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo-[4.4.0]decan-5-yl]ethyl]-2-oxo-1,2-dihydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc / toluene; N,N-dimethyl-formamide; diethyl ether / 20 - 35 °C

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 3 h / 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / -40 - 20 °C

3.2: 168 h / 20 °C / Inert atmosphere

4.1: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium hydride; zinc; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; toluene; paraffin oil; 1.1: |Barbier Coupling Reaction;
DOI:10.5560/ZNB.2012-0108