(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne

Base Information

Chemical Name:(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne
CAS No.:1403989-46-7
Molecular Formula:C₂₅H₂₈O₇
Molecular Weight:440.493
Hs Code.:

Synonyms:(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne

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Technology Process of (1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne

There total 6 articles about (1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1403989-41-2
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-hydroxybut-3-yne

: 74-88-4
methyl iodide

: 1403989-46-7
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; paraffin oil; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.5560/ZNB.2012-0108

Reference yield:

: 1403989-38-7
C₂₁H₂₄O₈

: 1403989-46-7
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / Reflux

2: zinc / toluene; N,N-dimethyl-formamide; diethyl ether / 20 - 35 °C

3: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 3 h / 20 °C / Inert atmosphere

With sodium hydride; zinc; In diethyl ether; N,N-dimethyl-formamide; toluene; paraffin oil; 2: |Barbier Coupling Reaction;
DOI:10.5560/ZNB.2012-0108

Reference yield:

: 143616-91-5
(1S,3S,5R,6R,8R)-5-<(1R)-1,2-Dihydroxyethyl>-3,8-di(4-methoxyhenyl)-2,4,7,9-tetraoxabicyclo<4.4.0>decane

: 1403989-46-7
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne

Guidance literature:: Multi-step reaction with 3 steps

1: sodium periodate / 1,4-dioxane; water / 48 h / 20 °C

2: zinc / toluene; N,N-dimethyl-formamide; diethyl ether / 20 - 35 °C

3: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 3 h / 20 °C / Inert atmosphere

With sodium periodate; sodium hydride; zinc; In 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide; toluene; paraffin oil; 2: |Barbier Coupling Reaction;
DOI:10.5560/ZNB.2012-0108