(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne

Base Information

Chemical Name:(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne
CAS No.:1403989-48-9
Molecular Formula:C₃₂H₄₅N₃O₇
Molecular Weight:583.725
Hs Code.:

Synonyms:(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne

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Chemical Property of (1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne

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Technology Process of (1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne

There total 7 articles about (1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403989-46-7
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne

: 30388-20-6
N,N,N',N',N'',N''-hexamethylguanidinium chloride

: 1403989-48-9
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne

Guidance literature:: (1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxybut-3-yne; With n-butyllithium; In tetrahydrofuran; hexane; at -40 - 20 ℃;

N,N,N',N',N'',N''-hexamethylguanidinium chloride; In tetrahydrofuran; hexane; at 20 ℃; for 168h; Inert atmosphere;
DOI:10.5560/ZNB.2012-0108

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1403989-48-9
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 20 - 70 °C

2.1: sodium periodate / 1,4-dioxane; water / 48 h / 20 °C

3.1: zinc / toluene; N,N-dimethyl-formamide; diethyl ether / 20 - 35 °C

4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 3 h / 20 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / -40 - 20 °C

5.2: 168 h / 20 °C / Inert atmosphere

With sodium periodate; n-butyllithium; sodium hydride; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; water; N,N-dimethyl-formamide; toluene; paraffin oil; 3.1: |Barbier Coupling Reaction;
DOI:10.5560/ZNB.2012-0108

Reference yield:

: 1403989-38-7
C₂₁H₂₄O₈

: 1403989-48-9
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-5,5,5-tris(dimethylamino)pent-3-yne

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / Reflux

2.1: zinc / toluene; N,N-dimethyl-formamide; diethyl ether / 20 - 35 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 3 h / 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / -40 - 20 °C

4.2: 168 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium hydride; zinc; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; toluene; paraffin oil; 2.1: |Barbier Coupling Reaction;
DOI:10.5560/ZNB.2012-0108