(+)-2-Diethylaminopropiophenone

Base Information

• Chemical Name: (+)-2-Diethylaminopropiophenone
• CAS No.: 39648-49-2
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.3
• UNII: I535TOV6LY
• Nikkaji Number: J3.448.832K
• Wikidata: Q27126881
• Metabolomics Workbench ID: 60780

Synonyms:(+)-Amfepramone;(S)-diethylpropion;Amfepramone, (+)-;(S)-amfepramone;I535TOV6LY;(2S)-diethylpropion;(+)-2-Diethylaminopropiophenone;Diethylpropion, (+}-;UNII-I535TOV6LY;(S)-alpha-benzoyltriethylamine;(2S)-2-(diethylamino)-1-phenylpropan-1-one;(S)-alpha-diethylaminopropiophenone;1-Propanone, 2-(diethylamino)-1-phenyl-, (+)-;39648-49-2;DIETHYLPROPION, (+)-;Amfepramone, (S)-;DIETHYLPROPION, (S)-;CHEBI:59747;Q27126881;1-PROPANONE, 2-(DIETHYLAMINO)-1-PHENYL-, (2S)-

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Chemical Property of (+)-2-Diethylaminopropiophenone

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 205.146664230
• Heavy Atom Count: 15
• Complexity: 193

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN(CC)C(C)C(=O)C1=CC=CC=C1
• Isomeric SMILES: CCN(CC)[C@@H](C)C(=O)C1=CC=CC=C1

Technology Process of (+)-2-Diethylaminopropiophenone

There total 15 articles about (+)-2-Diethylaminopropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

diethylamine (109-89-7) + (+/-)-cathinone (5265-18-9) → amfepramone (90-84-6,39648-49-2,39648-50-5)

Guidance literature:

at 90 ℃; for 1.5h; Temperature;

Reference yield: 85.0%

2-bromo-1-phenyl-1-propanone (2114-00-3) + diethylamine (109-89-7) → amfepramone (90-84-6,39648-49-2,39648-50-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; at 40 ℃; for 16h;

DOI:10.1021/jo049677l

Reference yield: 80.0%

diethylamine (109-89-7) + 1-phenyl-propan-1-one (93-55-0) → amfepramone (90-84-6,39648-49-2,39648-50-5)

Guidance literature:

1-phenyl-propan-1-one; With 1,10-Phenanthroline; copper(ll) bromide; In dimethyl sulfoxide; at 20 ℃; for 0.166667h;

diethylamine; With oxygen; In dimethyl sulfoxide; at 35 ℃; for 1.5h; under 760.051 Torr; Sealed tube;

DOI:10.1021/ja4096472

upstream raw materials:

2-bromo-1-phenyl-1-propanone

diethylamine

N,N-diethylphenacylamine

1-phenyl-propan-1-one

Downstream raw materials:

2-Diethylamino-1-phenyl-propan-1-ol

2-Diethylamino-1-phenyl-propan-1-ol