C₁₆H₁₁F₄N₃O₃

Base Information

• Chemical Name: C₁₆H₁₁F₄N₃O₃
• CAS No.: 1415359-43-1
• Molecular Formula: C₁₆H₁₁F₄N₃O₃
• Molecular Weight: 369.275
• Mol file: 1415359-43-1.mol

Synonyms:

Chemical Property of C₁₆H₁₁F₄N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₁F₄N₃O₃

There total 5 articles about C₁₆H₁₁F₄N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H17F3O5 → C16H11F4N3O3 (1415359-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: acetic acid

With acetic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2012.10.034

Reference yield:

5-(trifluoromethyl)furan-2-carboxylic acid (56286-73-8) → C16H11F4N3O3 (1415359-43-1)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C

2: triethylamine; magnesium chloride / acetonitrile

3: trifluoroacetic acid / dichloromethane

4: acetic acid

With oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; magnesium chloride; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2012.10.034

Reference yield:

(5-(trifluoromethyl)furan-2-yl)methanol (65865-28-3) → C16H11F4N3O3 (1415359-43-1)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium chlorite; 2-methyl-but-2-ene; Dess-Martin periodane / dichloromethane; tert-butyl alcohol; aq. phosphate buffer / pH 7

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C

3: triethylamine; magnesium chloride / acetonitrile

4: trifluoroacetic acid / dichloromethane

5: acetic acid

With sodium chlorite; 2-methyl-but-2-ene; oxalyl dichloride; Dess-Martin periodane; acetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; magnesium chloride; In aq. phosphate buffer; dichloromethane; acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2012.10.034

upstream raw materials:

C₆H₆FN₃O₂

C₁₀H₉F₃O₃

(5-(trifluoromethyl)furan-2-yl)methanol

5-(trifluoromethyl)furan-2-carboxylic acid

Downstream raw materials:

C₂₄H₂₂F₃N₅O₄

C₂₄H₂₂F₃N₅O₄

C₃₀H₂₂F₃N₅O₅

C₃₁H₂₄F₃N₅O₅