56286-73-8

Usage

Uses

Used in Pharmaceutical Research and Development:
5-(TRIFLUOROMETHYL)-2-FUROIC ACID, 97 is utilized as a key intermediate in the synthesis of new drugs, leveraging its unique reactivity to contribute to the creation of novel pharmaceutical agents. Its potential in drug development is attributed to its capacity to enhance the properties of compounds, such as potency, selectivity, and metabolic stability.
Used in Agrochemical Development:
In the agrochemical industry, 5-(TRIFLUOROMETHYL)-2-FUROIC ACID, 97 is employed as a building block for the development of new agrochemicals. Its unique structure allows for the design of compounds with improved pesticidal properties, such as increased effectiveness against pests and resistance to environmental degradation.
Used in Organic Synthesis:
5-(TRIFLUOROMETHYL)-2-FUROIC ACID, 97 is used as a versatile intermediate in organic synthesis, enabling the production of a wide range of specialty chemicals. Its reactivity and structural features facilitate the synthesis of complex organic molecules for various applications, including materials science, fragrances, and flavorings.
Used in Research and Development Processes:
This chemical compound is primarily used in research and development processes, where it serves as a valuable tool for scientists to explore new chemical reactions and synthesize novel compounds. Its presence in the lab is significant for advancing knowledge in organic chemistry and related fields.
It is important to handle 5-(TRIFLUOROMETHYL)-2-FUROIC ACID, 97 with care and adhere to safety protocols when working with this chemical, given its reactivity and potential applications in sensitive areas such as drug and agrochemical development.

InChI:InChI=1/C6H3F3O3/c7-6(8,9)4-2-1-3(12-4)5(10)11/h1-2H,(H,10,11)

Upstream product

• 65865-28-3 (5-(trifluoromethyl)furan-2-yl)methanol 
• 88-14-2 2-furanoic acid 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 3238-40-2 furan-2,5-dicarboxylic acid 

Downstream Products

• 65865-28-3 (5-(trifluoromethyl)furan-2-yl)methanol 
• 1421458-34-5 C₃₀H₂₂F₃N₅O₅ 
• 1421458-57-2 C₃₁H₂₄F₃N₅O₅ 
• 1415359-43-1 C₁₆H₁₁F₄N₃O₃ 
• 65865-25-0 5-(trifluoromethyl)furan-2-carbonyl chloride 
• 1421455-10-8 C₂₃H₂₀F₃N₅O₄ 
• 1421455-11-9 C₂₄H₂₂F₃N₅O₄ 
• 1421455-12-0 C₂₄H₂₂F₃N₅O₄ 
• 1421455-14-2 C₂₃H₂₂F₃N₅O₂ 
• 1421455-15-3 C₂₄H₂₄F₃N₅O₂ 
• 1421455-16-4 C₂₄H₂₄F₃N₅O₂ 
• 1415359-54-4 C₃₁H₂₄F₃N₅O₅ 
• 1415359-55-5 C₃₂H₂₆F₃N₅O₅ 
• 1415359-56-6 C₃₂H₂₆F₃N₅O₅ 

Relevant academic research and scientific papers

Trifluoromethanesulfonic Anhydride as a Low-Cost and Versatile Trifluoromethylation Reagent

A large number of reagents have been developed for the synthesis of trifluoromethylated compounds. However, an ongoing challenge in trifluoromethylation reaction is the use of less expensive and practical trifluoromethyl sources. We report herein the unprecedented direct trifluoromethylation of (hetero)arenes using trifluoromethanesulfonic anhydride as a radical trifluoromethylation reagent by merging photoredox catalysis and pyridine activation. Furthermore, introduction of both the CF3 and OTf groups of the trifluoromethanesulfonic anhydride into internal alkynes to access tetrasubstituted trifluoromethylated alkenes was achieved. Since trifluoromethanesulfonic anhydride is a low-cost and abundant chemical, this method provides a cost-efficient and practical route to trifluoromethylated compounds.

Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol- 1-yl)-1H-benzimidazole scaffold

A uHTS campaign led to the discovery of a 5-(5-furan-2-ylpyrazol-1-yl)-1H- benzimidazole series that inhibits assembly of HIV-1 capsid. Synthetic manipulations at N1, C2 and C16 positions improved the antiviral potency by a. The X-ray structure of 33 complexed with the capsid N-terminal domain allowed identification of major interactions between the inhibitor and the protein.

SYNTHESIS AND POLYMERISATION OF ETHYNYLTHIOPHENES AND ETHYNYLFURANS CONTAINING TRIFLUORMETHYL GROUPS

Fluorination of thiophenedicarboxylic acid with sulfur tetrafluoride in the presence of anhydrous hydrogen fluoride provided mono and bis(trifluoromethyl)thiophenes in moderate yields.Ethynylthiophenes and ethynylfurans containing trifluoromethyl groups were prepared via 2,2-dichloro-1-fluorovinyl compounds.In polymerizations using transitions metal catalysts, 3-ethynylthiophenes gave polymers in high yields, which were soluble in THF and/or fluorocompounds, while 2-ethynylthiophenes polymerized in low yields.In γ-ray induced polymerization, only 2,5-bis(trifluoromethyl)-3-ethynylthiophene afforded the corresponding polymers.Thermal decomposition temperatures of polymers obtained increased by introduction of the trifluoromethyl groups as well as the methyl groups.