(Rp)-ortho-diphenylphosphanylferrocene carboxylic acid

Base Information

• Chemical Name: (Rp)-ortho-diphenylphosphanylferrocene carboxylic acid
• CAS No.: 1144039-25-7
• Molecular Formula: C₂₃H₁₉FeOP
• Molecular Weight: 398.224
• Mol file: 1144039-25-7.mol

Synonyms:

Chemical Property of (Rp)-ortho-diphenylphosphanylferrocene carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (Rp)-ortho-diphenylphosphanylferrocene carboxylic acid

There total 6 articles about (Rp)-ortho-diphenylphosphanylferrocene carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(C5H5)Fe(C5H3(P(C6H5)2)C(O)OCH(CH2C(CH2)CH(CH3)2)CH2CH(CH(CH3)2)CH2CHO) + potassium hydroxide + trimethyl orthoformate (149-73-5) → (Rp)-ortho-diphenylphosphanylferrocene carboxylic acid (149095-48-7,1144039-25-7) + (3S,5S)-3-isopropyl-1,1-dimethoxy-8-methyl-7-methylene-nonan-5-ol (766528-45-4)

Guidance literature:

With TsOH; In ethanol; Fe complex treated with HC(OMe)3 and TsOH in MeOH under heating; heated with KOH in EtOH;

DOI:10.1021/ja0467364

Reference yield: 87.0%

1-bromo-2-(diphenylphosphino)ferrocene (1094756-39-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → (S)-α-(diphenylphosphino)ferrocenecarboxaldehyde (1144039-25-7,149095-48-7)

Guidance literature:

1-bromo-2-(diphenylphosphino)ferrocene; With n-butyllithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h; Inert atmosphere; Schlenk technique; Glovebox;

N,N-dimethyl-formamide; In tetrahydrofuran; pentane; at -78 - 20 ℃; for 1.5h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1002/ejic.201601440

Reference yield: 74.0%

C28H29FeO3P (149095-44-3) → (Rp)-ortho-diphenylphosphanylferrocene carboxylic acid (149095-48-7,1144039-25-7)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; water; at 45 ℃;

DOI:10.1021/ja413060u

upstream raw materials:

ferrocenecarboxaldehyde

chloro-diphenylphosphine

2-ferrocenyl-1,3-dioxane

1-bromo-2-(diphenylphosphino)ferrocene

Downstream raw materials:

C₂₄H₂₁FeP