1-Pyrrolidinecarboxylic acid, 2-[[(1-methylethyl)[(pentafluorophenoxy)carbonyl]amino]acetyl]-, 1,1-dimethylethyl ester, (S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[[(1-methylethyl)[(pentafluorophenoxy)carbonyl]amino]acetyl]-, 1,1-dimethylethyl ester, (S)-
CAS No.:102284-45-7
Molecular Formula:C21H25F5N2O5
Molecular Weight:480.432
Hs Code.:
Mol file:102284-45-7.mol

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[[(1-methylethyl)[(pentafluorophenoxy)carbonyl]amino]acetyl]-, 1,1-dimethylethyl ester, (S)-

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[[(1-methylethyl)[(pentafluorophenoxy)carbonyl]amino]acetyl]-, 1,1-dimethylethyl ester, (S)-

There total 3 articles about 1-Pyrrolidinecarboxylic acid, 2-[[(1-methylethyl)[(pentafluorophenoxy)carbonyl]amino]acetyl]-, 1,1-dimethylethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 36919-02-5
pentafluorophenyl chloroformate

: 102284-42-4
N-<(N-boc-L-propyl)methyl>isopropylamine

: 102284-45-7
pentafluorophenyl N-<(N-boc-L-prolyl)methyl>-N-isopropylcarbamate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 5 ℃; for 2h;
DOI:10.1021/jm00158a025

Reference yield:

: 102284-41-3
N-boc-L-prolyl chloromethyl ketone

: 102284-45-7
pentafluorophenyl N-<(N-boc-L-prolyl)methyl>-N-isopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / sodium iodide / aq. ethanol / 15 h / 65 °C

2: 80 percent / Et₃N / tetrahydrofuran / 2 h / 5 °C

With triethylamine; sodium iodide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00158a025

Reference yield:

: 101130-03-4
2,2-Dimethyl-propionic acid (S)-2-(2-diazo-acetyl)-pyrrolidin-1-yl ester

: 102284-45-7
pentafluorophenyl N-<(N-boc-L-prolyl)methyl>-N-isopropylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 51.7 percent / HCl

2: 56 percent / sodium iodide / aq. ethanol / 15 h / 65 °C

3: 80 percent / Et₃N / tetrahydrofuran / 2 h / 5 °C

With hydrogenchloride; triethylamine; sodium iodide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00158a025