4-acetyl-3-hydroxybenzoic acid

Base Information

• Chemical Name: 4-acetyl-3-hydroxybenzoic acid
• CAS No.: 102297-62-1
• Molecular Formula: C9H8O4
• Molecular Weight: 180.16
• Hs Code.: 2918999090
• Mol file: 102297-62-1.mol

Synonyms:4-Acetyl-3-hydroxy-benzoic acid;4-acetyl-3-hydroxybenzoic Acid;

Chemical Property of 4-acetyl-3-hydroxybenzoic acid

Chemical Property:

• Boiling Point: 379.9±32.0 °C(Predicted)
• PKA: 3.58±0.10(Predicted)
• PSA: 74.60000
• Density: 1.365±0.06 g/cm3(Predicted)
• LogP: 1.29300

Purity/Quality:

99% ^*data from raw suppliers

4-Acetyl-3-hydroxybenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-acetyl-3-hydroxybenzoic acid

There total 5 articles about 4-acetyl-3-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

carbon monoxide (201230-82-2) + 4'-bromo-2'-hydroxyacetophenone (30186-18-6) → 3-hydroxy-4-(1-oxo-ethane)benzoic acid (102297-62-1)

Guidance literature:

With water; potassium acetate; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In tetrahydrofuran; at 150 ℃; for 3h; under 38002.6 Torr;

Reference yield: 79.0%

4'-bromo-2'-hydroxyacetophenone (30186-18-6) + copper(I) cyanide (544-92-3) → 3-hydroxy-4-(1-oxo-ethane)benzoic acid (102297-62-1)

Guidance literature:

In N,N-dimethyl-formamide; for 3h; Heating;

Reference yield: 18.0%

3-acetoxybenzoic acid (6304-89-8) → 3-hydroxy-4-(1-oxo-ethane)benzoic acid (102297-62-1)

Guidance literature:

With aluminium trichloride; at 160 ℃; for 3h;

DOI:10.1021/jm960628d

upstream raw materials:

2-acetoxy-4-methylacetophenone

4'-bromo-2'-hydroxyacetophenone

copper(I) cyanide

3-acetoxybenzoic acid

Downstream raw materials:

ethyl 4-acetyl-3-hydroxybenzoate

ethyl 2,2-dimethyl-4-oxochromane-7-carboxylate

1-(4-acetyl-3-hydroxy-benzoylamino)-cycloheptanecarboxylic acid methyl ester

4-Acetyl-3-methoxybenzoesaeure-methylester

Refernces

• 1、 -. "KINASE INHIBITORS". Page/Page column 48-49. . Retrieved 2008/06/13.
• 2、 Zwaagstra, Mari?l E.,Timmerman, Hendrik,Tamura, Masahiro,Tohma, Tsutomu,Wada, Yasushi,Onogi, Kazuhiro,Zhang, Ming-Qiang. "Synthesis and structure-activity relationships of carboxylated chalcones: A novel series of CysLT1 (LTD4) receptor antagonists". . p. 1075 - 1089. Retrieved 2007/10/03.