1-(5-Fluoro-2-methoxyphenyl)piperazine

Base Information

Chemical Name:1-(5-Fluoro-2-methoxyphenyl)piperazine
CAS No.:102392-07-4
Molecular Formula:C11H15FN2O
Molecular Weight:210.251
Hs Code.:
ChEMBL ID:CHEMBL4576637
DSSTox Substance ID:DTXSID60593549
Wikidata:Q82488047
Mol file:102392-07-4.mol

Synonyms:1-(5-fluoro-2-methoxyphenyl)piperazine;102392-07-4;4-(5-fluoro-2-methoxyphenyl)-piperazine;SCHEMBL2873088;CHEMBL4576637;DTXSID60593549;LYPKLJIYXQVTPF-UHFFFAOYSA-N;GS1437;MFCD11872760;AKOS010941351;1-(2-Methoxy-5-fluorophenyl)piperazine;1-(5-fluoro-2-methoxy phenyl)piperazine;DB-180233;1-(5-Fluoro-2-methoxyphenyl)piperazine, 95%;EN300-112202;F94321

Suppliers and Price of 1-(5-Fluoro-2-methoxyphenyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 1-(5-Fluoro-2-methoxyphenyl)piperazine

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:210.11684127
Heavy Atom Count:15
Complexity:197

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)F)N2CCNCC2

Technology Process of 1-(5-Fluoro-2-methoxyphenyl)piperazine

There total 4 articles about 1-(5-Fluoro-2-methoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1978-39-8
5-fluoro-2-methoxy-aniline

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 102392-07-4
1-(2-methoxy-5-fluoro-phenyl)piperazine

Guidance literature:: In 5,5-dimethyl-1,3-cyclohexadiene; water;

Reference yield:

: C₁₆H₂₃FN₂O₃

: 102392-07-4
1-(2-methoxy-5-fluoro-phenyl)piperazine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1016/j.bmcl.2016.02.050

Reference yield:

: 452-08-4
2-bromo-4-fluoro-1-methoxybenzene

: 102392-07-4
1-(2-methoxy-5-fluoro-phenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; XPhos; sodium t-butanolate / toluene / 90 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; palladium diacetate; sodium t-butanolate; XPhos; In 1,4-dioxane; toluene; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2016.02.050