5-Fluoro-2-methoxyaniline

Base Information

• Chemical Name: 5-Fluoro-2-methoxyaniline
• CAS No.: 1978-39-8
• Molecular Formula: C7H8FNO
• Molecular Weight: 155.172
• Hs Code.: 2922299090
• Mol file: 1978-39-8.mol

Synonyms:o-Anisidine,5-fluoro- (6CI);2-Amino-4-fluoroanisole;2-Methoxy-5-fluoroaniline;4-Fluoro-2-aminoanisole;5-Fluoro-o-anisidine;NSC10341;

Chemical Property of 5-Fluoro-2-methoxyaniline

Chemical Property:

• Appearance/Colour: COLORLESS TO ORANGE LIQUID
• Vapor Pressure: 0.0532mmHg at 25°C
• Melting Point: 3 °C
• Refractive Index: n20/D 1.5438
• Boiling Point: 234.3 °C at 760 mmHg
• PKA: 3.52±0.10(Predicted)
• Flash Point: 95.5 °C
• PSA: 35.25000
• Density: 1.176 g/cm³
• LogP: 1.99770
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-2-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 5-Fluoro-2-methoxyaniline was used in the study of structure-activity relationship to discover selective inhibitors of p97 ATPase.

Technology Process of 5-Fluoro-2-methoxyaniline

There total 10 articles about 5-Fluoro-2-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-fluoro-2-methoxy-1-nitrobenzene (448-19-1) → 5-fluoro-2-methoxy-aniline (1978-39-8)

Guidance literature:

Reference yield: 92.0%

4-fluoro-1-methoxy-2-nitrobenzene (445-83-0) → 5-fluoro-2-methoxy-aniline (1978-39-8)

Guidance literature:

With iron(III) chloride; pyrographite; hydrazine hydrate; In ethanol; for 12h; Heating;

DOI:10.1135/cccc19820072

Reference yield: 75.0%

2-chloro-4-fluoro-1-methoxy-benzene (2267-25-6) → 5-fluoro-2-methoxy-aniline (1978-39-8)

Guidance literature:

With ammonium hydroxide; potassium phosphate; copper(l) iodide; N¹,N²-bis(2,4,6-trimethoxyphenyl)oxalamide; In water; dimethyl sulfoxide; at 120 ℃; for 48h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03230

upstream raw materials:

4-fluoro-1-methoxy-2-nitrobenzene

acetic acid-(5-fluoro-2-methoxy-anilide)

2-nitro-4-fluorophenol

1-fluoro-4-methoxybenzene

Downstream raw materials:

2-chloro-3-(5-fluoro-2-methoxy-phenyl)-propionaldehyde

[2-(tert-butoxycarbonylamino)-7-fluoro-1,3-benzothiazol-4-yl]boronic acid

O-isopropyl 5-fluoro-2-methoxyphenylthiocarbamate

2-methoxy-4-bromo-5-fluoroaniline