Technology Process of 2-Hexynoic acid, 6-(phenylmethoxy)-, methyl ester
There total 4 articles about 2-Hexynoic acid, 6-(phenylmethoxy)-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-benzyloxy-1-pentyne;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
chloroformic acid ethyl ester;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 1h;
Further stages.;
DOI:10.1021/ja063860+
- Guidance literature:
-
5-benzyloxy-1-pentyne;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1.33333h;
Inert atmosphere;
Schlenk technique;
methyl chloroformate;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 16h;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/chem.201304284
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere; Schlenk technique
1.2: 20 °C / Inert atmosphere; Schlenk technique
2.1: n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -78 °C / Inert atmosphere; Schlenk technique
2.2: 16 h / -78 - 20 °C / Inert atmosphere; Schlenk technique
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran; hexane; mineral oil;
DOI:10.1002/chem.201304284
