N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](chloroacetyl)amino}benzoyl)glutamic acid

Base Information

Chemical Name:N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](chloroacetyl)amino}benzoyl)glutamic acid
CAS No.:80402-32-0
Molecular Formula:C21H20 Cl N7 O7
Molecular Weight:517.8792
Hs Code.:

Synonyms:10-(Chloroacetyl)folicacid; NSC 309129

Suppliers and Price of N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](chloroacetyl)amino}benzoyl)glutamic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](chloroacetyl)amino}benzoyl)glutamic acid

Chemical Property:

Density:1.69g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](chloroacetyl)amino}benzoyl)glutamic acid

There total 1 articles about N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](chloroacetyl)amino}benzoyl)glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 65165-92-6
folate

: 79-04-9
chloroacetyl chloride

: 80402-32-0
10-(chloroacetyl)folic acid

Guidance literature:: In N,N-dimethyl acetamide; for 20h; Ambient temperature;
DOI:10.1021/jm00344a014

Reference yield: 5.0%

: 80402-32-0
10-(chloroacetyl)folic acid

: 5,10-Methenyltetrahydrofolat

: 10-acetyl-5,6,7,8-tetrahydrofolic acid

: 80402-38-6
5,6,7,8-tetrahydro-N⁵,N¹⁰-(2-oxoethylene)folic acid calcium salt

Guidance literature:: With calcium hydroxide; hydrogen; platinum; In trifluoroacetic acid; for 3.5h; under 760 Torr; Ambient temperature;
DOI:10.1021/jm00344a014

Reference yield:

: 80402-32-0
10-(chloroacetyl)folic acid

: 5,10-Methenyltetrahydrofolat

: 10-acetyl-5,6,7,8-tetrahydrofolic acid

: 5,6,7,8-tetrahydro-N⁵,N¹⁰-(2-oxoethylene)folic acid

Guidance literature:: With hydrogen; platinum; In trifluoroacetic acid; for 3.5h; under 760 Torr; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1021/jm00344a014