N-Benzhydrylpropionamide

Base Information

• Chemical Name: N-Benzhydrylpropionamide
• CAS No.: 10253-95-9
• Molecular Formula: C16H17NO
• Molecular Weight: 239.317
• European Community (EC) Number: 666-222-0
• DSSTox Substance ID: DTXSID10400037
• Nikkaji Number: J1.907.144H
• Wikidata: Q82202852
• Mol file: 10253-95-9.mol

Synonyms:N-Benzhydrylpropionamide;10253-95-9;Propanamide, N-(diphenylmethyl)-;starbld0032791;SCHEMBL14263838;DTXSID10400037;N-DIPHENYLMETHYLPROPIONAMIDE;AKOS001299753;Z26725407

Chemical Property of N-Benzhydrylpropionamide

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 239.131014166
• Heavy Atom Count: 18
• Complexity: 234

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)NC(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of N-Benzhydrylpropionamide

There total 7 articles about N-Benzhydrylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1,1-Diphenylmethanol (91-01-0) + propiononitrile (107-12-0) → N-(diphenylmethyl)-propylamide (10253-95-9)

Guidance literature:

With water; bismuth(III) bromide; at 120 ℃; for 48h;

DOI:10.1002/ejoc.201801882

Reference yield: 92.0%

propiononitrile (107-12-0) + Benzhydrylamine (91-00-9) → N-(diphenylmethyl)-propylamide (10253-95-9)

Guidance literature:

With o-chloranil; boric acid; for 4h; Heating;

DOI:10.1021/ol060216r

Reference yield: 53.0%

propionyl chloride (79-03-8) + Benzhydrylamine (91-00-9) → N-(diphenylmethyl)-propylamide (10253-95-9)

Guidance literature:

With pyridine; In benzene; for 1h; Heating;

DOI:10.1007/BF00764709 DOI:10.1007/BF00769646

upstream raw materials:

Bromodiphenylmethane

propiononitrile

1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one

Benzhydrylamine

Downstream raw materials:

N-(Diphenylmethylen)propionamid

Refernces

• 1、 Audiger, Logan,Watts, Kevin,Elmore, Simon C.,Robinson, Richard I.,Wirth, Thomas. "Ritter reactions in flow". . p. 257 - 260. Retrieved 2012.
• 2、 Gullickson, Glen C.,Lewis, David E.. "Synthesis of n-benzhydrylamides from nitriles by ritter reactions in formic acid". . p. 681 - 684. Retrieved 2003.
• 3、 Kashima, Choji,Fukuchi, Iwao,Takahashi, Katsumi,Hosomi, Akira. "Aminolysis of N-Acylpyrazoles". . p. 1407 - 1412. Retrieved 1994.