1-Boc-3-ethoxycarbonyl-3-(Boc-amino)azetidine

Base Information

• Chemical Name: 1-Boc-3-ethoxycarbonyl-3-(Boc-amino)azetidine
• CAS No.: 1105662-59-6
• Molecular Formula: C₁₆H₂₈N₂O₆
• Molecular Weight: 344.408
• Mol file: 1105662-59-6.mol

Synonyms:

Chemical Property of 1-Boc-3-ethoxycarbonyl-3-(Boc-amino)azetidine

Chemical Property:

• Boiling Point: 427.5±45.0 °C(Predicted)
• PKA: 9.89±0.20(Predicted)
• Density: 1.15±0.1 g/cm3(Predicted)

Purity/Quality:

98.5% ^*data from raw suppliers

Ethyl1-Boc-3-(Boc-amino)azetidine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-3-ethoxycarbonyl-3-(Boc-amino)azetidine

There total 1 articles about 1-Boc-3-ethoxycarbonyl-3-(Boc-amino)azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

azetidine-1,3,3-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester (1011479-76-7) + tert-butyl alcohol (75-65-0) → 3-tert-butoxycarbonylamino-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (1105662-59-6)

Guidance literature:

azetidine-1,3,3-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester; With diphenyl phosphoryl azide; triethylamine; In toluene; at 80 ℃; for 4h;

tert-butyl alcohol; In toluene; for 4h;

Reference yield:

3-tert-butoxycarbonylamino-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (1105662-59-6) → tert-butyl 3-((tert-butoxycarbonyl)amino)-3-(hydroxymethyl)azetidine-1-carboxylate (1105662-61-0)

Guidance literature:

3-tert-butoxycarbonylamino-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester; With lithium borohydride; In tetrahydrofuran; for 0.333333h;

With water; In tetrahydrofuran;

upstream raw materials:

azetidine-1,3,3-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester

tert-butyl alcohol

Downstream raw materials:

tert-butyl 3-((tert-butoxycarbonyl)amino)-3-(hydroxymethyl)azetidine-1-carboxylate

Refernces