1H-Indol-2-yl(p-tolyl) ketone

Base Information

• Chemical Name: 1H-Indol-2-yl(p-tolyl) ketone
• CAS No.: 1026-21-7
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Mol file: 1026-21-7.mol

Synonyms:(1H-indol-2-yl)-p-tolyl-methanone;2-(4-Methyl-benzoyl)-indol;(1H-indol-2-yl)(p-tolyl)methanone;2-p-Methylbenzoylindol;indol-2-yl-p-tolyl-methanone;

Chemical Property of 1H-Indol-2-yl(p-tolyl) ketone

Chemical Property:

• PSA: 32.86000
• LogP: 3.70730

Purity/Quality:

98%,99%, ^*data from raw suppliers

1H-INDOL-2-YL(4-METHYLPHENYL)METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indol-2-yl(p-tolyl) ketone

There total 19 articles about 1H-Indol-2-yl(p-tolyl) ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.4%

4-methylphenylglyoxal (1075-47-4) + 2-aminophenylacetonitrile (2973-50-4) → (1H-indol-2-yl)(4-methyphenyl)methanone (1026-21-7)

Guidance literature:

With 1-(diphenylphosphino)ferrocene-1-(di-tert-butylphosphino)ferrocene; 1-cyanopropyl-3-methylimidazolium tetrafluoroborate; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; tin(IV) iodide; cerium triflate; In ethylene glycol; at 100 ℃; for 8h; Reagent/catalyst;

Reference yield: 89.0%

Indole-2-carbonyl chloride (58881-45-1) + 4-methylphenylboronic acid (5720-05-8) → (1H-indol-2-yl)(4-methyphenyl)methanone (1026-21-7)

Guidance literature:

With potassium carbonate; tris-(o-tolyl)phosphine; palladium diacetate; In toluene; at 50 ℃; for 1h;

DOI:10.1021/ol061872u

Reference yield: 78.0%

4-methylphenacylidenedimethylsulphurane (18631-55-5) + N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide (243844-35-1) → (1H-indol-2-yl)(4-methyphenyl)methanone (1026-21-7)

Guidance literature:

4-methylphenacylidenedimethylsulphurane; With caesium carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 20 ℃; for 0.5h;

N-[2-(chloromethyl)-phenyl]-4-methylbenzene-1-sulfonamide; In 5,5-dimethyl-1,3-cyclohexadiene; at 20 ℃;

DOI:10.1002/anie.201203657

upstream raw materials:

Indole-2-carbonyl chloride

4-methylphenylboronic acid

p-toluoyl-1H-1,2,3-benzotriazole

2-azidobenzaldehyde

Downstream raw materials:

1-p-tolyl-3H-pyrrolo[1,2-a]indole-2-carbaldehyde

(1-prop-2-ynyl-1H-indol-2-yl)-p-tolyl-methanone

Refernces

• 1、 Qu, Zhonghua,Wang, Pu,Chen, Xing,Deng, Guo-Jun,Huang, Huawen. "Visible-light-driven Cadogan reaction". supporting information. p. 2582 - 2586. Retrieved 2021/03/09.