phenyl-thiophosphonigsaeure-O-ethylester

Base Information

• Chemical Name: phenyl-thiophosphonigsaeure-O-ethylester
• CAS No.: 6591-08-8
• Molecular Formula: C₈H₁₁OPS
• Molecular Weight: 186.214
• Mol file: 6591-08-8.mol

Synonyms:

Chemical Property of phenyl-thiophosphonigsaeure-O-ethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl-thiophosphonigsaeure-O-ethylester

There total 9 articles about phenyl-thiophosphonigsaeure-O-ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethanol (64-17-5) + phenylphosphinic acid (1779-48-2) → phenyl-thiophosphonigsaeure-O-ethylester (6591-08-8,135388-66-8,135388-67-9)

Guidance literature:

ethanol; phenylphosphinic acid; With dicyclohexyl-carbodiimide;

With Lawessons reagent;

DOI:10.1002/ejoc.200500907

Reference yield: 91.0%

O-ethyl phenylphosphonochloridothioate (5075-13-8) → phenyl-thiophosphonigsaeure-O-ethylester (6591-08-8,135388-66-8,135388-67-9)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; for 48h; Mechanism; Ambient temperature; also with optically active compounds; other P-Cl compounds;

DOI:10.1016/S0040-4039(00)74363-2

Reference yield: 78.5%

ethyl Phenylphosphinate (172487-18-2,2511-09-3) → phenyl-thiophosphonigsaeure-O-ethylester (6591-08-8,135388-66-8,135388-67-9)

Guidance literature:

With Lawessons reagent; In benzene; for 1h; Heating;

upstream raw materials:

phenyl-phosphonous acid ethyl ester-dimethylamide

ethyl Phenylphosphinate

ethanol

Dichlorophenylphosphine

Downstream raw materials:

5-deoxy-1,2-O-isopropylidene-3-O-methyl-5-C-phenylphosphinothioyl-α-D-xylofuranose

5-deoxy-3-O-methyl-5-C-(phenylphosphinothioyl)-D-xylopyranose

4-(ethoxy-phenyl-phosphinothioylsulfanyl)-morpholine

5-deoxy-5-C-<(ethoxy)phenylphosphinothioyl>-1,2-O-isopropylidene-3-O-methyl-α-D-xylofuranose

Refernces

• 1、 Jessop, Christopher M.,Parsons, Andrew F.,Routledge, Anne,Irvine, Derek J.. "Radical addition reactions of phosphorus hydrides: Tuning the reactivity of phosphorus hydrides, the use of microwaves and horner-wadsworth-emmons-type reactions". . p. 1547 - 1554. Retrieved 2007/10/03.
• 2、 Zabirov, N. G.,Cherkasov, R. A.,Pudovik, A. N.. "LAWESSON REAGENT IN ORGANOPHOSPHORUS SYNTHESIS I. METHOD FOR THE PREPARATION OF ACID PHOSPHOROTHIOITES AND PHOSPHONOTHIOATES". . p. 1047 - 1048. Retrieved 2007/10/02.