4-(3-Phenyl-1,2-oxazol-5-yl)morpholine

Base Information

• Chemical Name: 4-(3-Phenyl-1,2-oxazol-5-yl)morpholine
• CAS No.: 10285-00-4
• Molecular Formula: C13H14N2O2
• Molecular Weight: 230.266
• ChEMBL ID: CHEMBL3276990
• DSSTox Substance ID: DTXSID50494839
• Nikkaji Number: J2.640.277H
• Wikidata: Q82342503
• Mol file: 10285-00-4.mol

Synonyms:4-(3-Phenyl-1,2-oxazol-5-yl)morpholine;10285-00-4;CHEMBL3276990;DTXSID50494839

Chemical Property of 4-(3-Phenyl-1,2-oxazol-5-yl)morpholine

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 230.105527694
• Heavy Atom Count: 17
• Complexity: 238

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC(=NO2)C3=CC=CC=C3

Technology Process of 4-(3-Phenyl-1,2-oxazol-5-yl)morpholine

There total 8 articles about 4-(3-Phenyl-1,2-oxazol-5-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzonitrile oxide (873-67-6) + 2-morpholin-4-yl-acrylonitrile (5807-03-4) → 4-(3-phenylisoxazol-5-yl)morpholine (10285-00-4)

Guidance literature:

With triethylamine; In benzene; for 48h; regioselective reaction; Reflux;

DOI:10.1002/jhet.5570450521

Reference yield: 75.0%

morpholine (110-91-8,99108-56-2) + 5-bromo-3-phenylisoxazole (3356-92-1) → 4-(3-phenylisoxazol-5-yl)morpholine (10285-00-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1002/ejoc.201900187

Reference yield: 74.0%

morpholine (110-91-8,99108-56-2) + 3-phenyl-5-chloroisoxazole (3356-89-6) → 4-(3-phenylisoxazol-5-yl)morpholine (10285-00-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; Reagent/catalyst; Solvent; Temperature;

DOI:10.1002/ejoc.201900187

upstream raw materials:

1,1-bis(N-morpholinyl)ethylene

benzonitrile oxide

2-morpholin-4-yl-acrylonitrile

morpholine

Downstream raw materials:

3-phenyl-4H-isoxazol-5-one