Technology Process of C38H53N5O8
There total 8 articles about C38H53N5O8 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1021/jm301630s
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogen; palladium on activated charcoal / ethyl acetate / 2 h / 760.05 Torr
2: methanol / 3 h / 0 - 20 °C
3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0 - 20 °C
With
1-hydroxy-7-aza-benzotriazole; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm301630s
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogenchloride; water / ethyl acetate
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / dichloromethane
3: hydrogen; palladium on activated charcoal / ethyl acetate
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / dichloromethane
5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
6: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0 - 20 °C
With
hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; palladium on activated charcoal; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm301630s