C₂H₂O₄*C₁₈H₁₅BrF₂N₄O

Base Information

• Chemical Name: C₂H₂O₄*C₁₈H₁₅BrF₂N₄O
• CAS No.: 1395553-32-8
• Molecular Formula: C₂H₂O₄*C₁₈H₁₅BrF₂N₄O
• Molecular Weight: 511.28
• Mol file: 1395553-32-8.mol

Synonyms:

Chemical Property of C₂H₂O₄*C₁₈H₁₅BrF₂N₄O

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂H₂O₄*C₁₈H₁₅BrF₂N₄O

There total 5 articles about C₂H₂O₄*C₁₈H₁₅BrF₂N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-bromo-2,5-difluorophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine (1395553-31-7) + oxalic acid (144-62-7,97993-78-7) → C2H2O4*C18H15BrF2N4O (1395553-32-8)

Guidance literature:

In ethanol;

DOI:10.1016/j.bmc.2012.06.049

Reference yield:

4-bromo-2,5-difluorobenzoic acid (28314-82-1) → C2H2O4*C18H15BrF2N4O (1395553-32-8)

Guidance literature:

Multi-step reaction with 8 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 1.5 h / 80 °C

2.1: ammonium hydroxide / chloroform / 0.5 h / 5 °C

3.1: trichlorophosphate / 2 h / 80 °C

4.1: hydrogenchloride / chloroform; ethanol / 20 °C / Cooling

4.2: 20 °C

5.1: sodium methylate / methanol / 20 °C

6.1: trichlorophosphate / 2.5 h / 80 °C

7.1: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / 80 °C

8.1: ethanol

With 1,3-dimethyl-2-imidazolidinone; hydrogenchloride; ammonium hydroxide; thionyl chloride; sodium methylate; potassium carbonate; trichlorophosphate; In methanol; ethanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.06.049

Reference yield:

1,4-dibromo-2,5-difluorobenzene (327-51-5) → C2H2O4*C18H15BrF2N4O (1395553-32-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.03 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: thionyl chloride / N,N-dimethyl-formamide / 1.5 h / 80 °C

3.1: ammonium hydroxide / chloroform / 0.5 h / 5 °C

4.1: trichlorophosphate / 2 h / 80 °C

5.1: hydrogenchloride / chloroform; ethanol / 20 °C / Cooling

5.2: 20 °C

6.1: sodium methylate / methanol / 20 °C

7.1: trichlorophosphate / 2.5 h / 80 °C

8.1: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / 80 °C

9.1: ethanol

With 1,3-dimethyl-2-imidazolidinone; hydrogenchloride; ammonium hydroxide; n-butyllithium; thionyl chloride; sodium methylate; potassium carbonate; trichlorophosphate; In methanol; diethyl ether; ethanol; hexane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.06.049

upstream raw materials:

2-(4-bromo-2,5-difluorophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine

oxalic acid

4-bromo-2,5-difluorobenzoic acid

4-bromo-2,5-difluorobenzoic acid chloride