(+/-)-(1α,2β)-2-<2-amino-6-chloro-9H-purin-9-yl>-4,4-bis(benzyloxymethyl)-1-cyclopentanol

Base Information

Chemical Name:(+/-)-(1α,2β)-2-<2-amino-6-chloro-9H-purin-9-yl>-4,4-bis(benzyloxymethyl)-1-cyclopentanol
CAS No.:129778-04-7
Molecular Formula:C₂₆H₂₈ClN₅O₃
Molecular Weight:493.993
Hs Code.:

Synonyms:

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Chemical Property of (+/-)-(1α,2β)-2-<2-amino-6-chloro-9H-purin-9-yl>-4,4-bis(benzyloxymethyl)-1-cyclopentanol

Chemical Property:

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Technology Process of (+/-)-(1α,2β)-2-<2-amino-6-chloro-9H-purin-9-yl>-4,4-bis(benzyloxymethyl)-1-cyclopentanol

There total 6 articles about (+/-)-(1α,2β)-2-<2-amino-6-chloro-9H-purin-9-yl>-4,4-bis(benzyloxymethyl)-1-cyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76910-02-6
3-cyclopenten-1,1-dimethanol

: 129778-04-7
(+/-)-(1α,2β)-2-<2-amino-6-chloro-9H-purin-9-yl>-4,4-bis(benzyloxymethyl)-1-cyclopentanol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) sodium hydride, 2.) tetrabutylammonium hydrogen sulfate / 1.) THF, 2 h, 2.) 4 h

2: 100 percent / m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

3: 95 percent / sodium azide, ammonium chloride / 2-ethoxy-ethanol; H₂O / 18 h / Heating

4: 86 percent / triphenylphosphine / tetrahydrofuran; H₂O / 24 h / Heating

5: 0.37 g / triethylamine / butan-1-ol / 144 h / Heating

6: 81 percent / conc. HCl / N,N-dimethyl-acetamide / 1.) RRT, 2 days, 2.) reflux, 1 h

With hydrogenchloride; sodium azide; ammonium chloride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; 2-ethoxy-ethanol; dichloromethane; N,N-dimethyl acetamide; water; butan-1-ol;

Reference yield:

: 100-39-0
benzyl bromide

: 129778-04-7
(+/-)-(1α,2β)-2-<2-amino-6-chloro-9H-purin-9-yl>-4,4-bis(benzyloxymethyl)-1-cyclopentanol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) sodium hydride, 2.) tetrabutylammonium hydrogen sulfate / 1.) THF, 2 h, 2.) 4 h

2: 100 percent / m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

3: 95 percent / sodium azide, ammonium chloride / 2-ethoxy-ethanol; H₂O / 18 h / Heating

4: 86 percent / triphenylphosphine / tetrahydrofuran; H₂O / 24 h / Heating

5: 0.37 g / triethylamine / butan-1-ol / 144 h / Heating

6: 81 percent / conc. HCl / N,N-dimethyl-acetamide / 1.) RRT, 2 days, 2.) reflux, 1 h

With hydrogenchloride; sodium azide; ammonium chloride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; 2-ethoxy-ethanol; dichloromethane; N,N-dimethyl acetamide; water; butan-1-ol;

Reference yield:

: 129777-96-4
4,4-bis(benzyloxymethyl)-1-cyclopentene

: 129778-04-7
(+/-)-(1α,2β)-2-<2-amino-6-chloro-9H-purin-9-yl>-4,4-bis(benzyloxymethyl)-1-cyclopentanol

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

2: 95 percent / sodium azide, ammonium chloride / 2-ethoxy-ethanol; H₂O / 18 h / Heating

3: 86 percent / triphenylphosphine / tetrahydrofuran; H₂O / 24 h / Heating

4: 0.37 g / triethylamine / butan-1-ol / 144 h / Heating

5: 81 percent / conc. HCl / N,N-dimethyl-acetamide / 1.) RRT, 2 days, 2.) reflux, 1 h

With hydrogenchloride; sodium azide; ammonium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; 2-ethoxy-ethanol; dichloromethane; N,N-dimethyl acetamide; water; butan-1-ol;