Technology Process of tris-(2-<3--propanamido>ethyl)amine
There total 6 articles about tris-(2-<3--propanamido>ethyl)amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
N,N-dimethyl-formamide;
at 38 ℃;
for 40h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / Et3N, isobutyl chloroformate / tetrahydrofuran / 1.) -15 deg C, 3 h, 2.) r.t., 20 h
2: 80 percent / 60percent NaH / dimethylformamide / 3 h / 100 °C
3: 93 percent / NaOH / methanol / 1.5 h / Ambient temperature
4: 100 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC*HCl) / Ambient temperature
5: 73 percent / dimethylformamide / 40 h / 38 °C
With
sodium hydroxide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / Et3N, isobutyl chloroformate / tetrahydrofuran / 1.) -15 deg C, 3 h, 2.) r.t., 20 h
2: 80 percent / 60percent NaH / dimethylformamide / 3 h / 100 °C
3: 93 percent / NaOH / methanol / 1.5 h / Ambient temperature
4: 100 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC*HCl) / Ambient temperature
5: 73 percent / dimethylformamide / 40 h / 38 °C
With
sodium hydroxide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
