PEG9-t-butly ester

Base Information

• Chemical Name: PEG9-t-butly ester
• CAS No.: 1334177-84-2
• Molecular Formula: C₂₃H₄₆O₁₁
• Molecular Weight: 498.612
• Mol file: 1334177-84-2.mol

Synonyms:

Chemical Property of PEG9-t-butly ester

Chemical Property:

• Storage Temp.: 2-8°C
• Solubility.: Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

97% ^*data from raw suppliers

HO-PEG8-CH2CH2COO-t-Bu ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Hydroxy-PEG8-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of PEG9-t-butly ester

There total 1 articles about PEG9-t-butly ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.49%

tert-Butyl acrylate (1663-39-4,25232-27-3) + octaethylene glycol (5117-19-1) → tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate (1334177-84-2)

Guidance literature:

With sodium; In dichloromethane; at 25 ℃; for 12h;

Reference yield: 85.0%

tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate (1334177-84-2) + p-toluenesulfonyl chloride (98-59-9) → C30H52O13S (1345337-28-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c4nj00654b

Reference yield:

tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate (1334177-84-2) → C66H117NO29P2

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: potassium iodide; potassium carbonate / acetone / 60 °C / Inert atmosphere

With potassium carbonate; triethylamine; potassium iodide; In dichloromethane; acetone; 2: |Williamson Ether Synthesis;

DOI:10.1039/c4nj00654b

upstream raw materials:

tert-Butyl acrylate

octaethylene glycol

Downstream raw materials:

C₂₃H₄₅N₃O₁₀

C₃₀H₅₂O₁₃S