5,6,7,8-Tetrahydro-4H-thieno[2,3-d]azepine

Base Information

Chemical Name:5,6,7,8-Tetrahydro-4H-thieno[2,3-d]azepine
CAS No.:102997-01-3
Molecular Formula:C8H11NS
Molecular Weight:153.24500
Hs Code.:
European Community (EC) Number:848-269-0
DSSTox Substance ID:DTXSID80467814
Wikidata:Q82294892
Mol file:102997-01-3.mol

Synonyms:102997-01-3;5,6,7,8-Tetrahydro-4H-thieno[2,3-d]azepine;4H-Thieno[2,3-d]azepine, 5,6,7,8-tetrahydro-;4H,5H,6H,7H,8H-Thieno[2,3-d]azepine;SCHEMBL997292;DTXSID80467814;JUPMBVNRFXPRCB-UHFFFAOYSA-N;MFCD11044625;AKOS006307598;EN300-378129;5,6,7,8-tetrahydro-4H-thieno-[2,3-d]azepine

Suppliers and Price of 5,6,7,8-Tetrahydro-4H-thieno[2,3-d]azepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5,6,7,8-TETRAHYDRO-4H-THIENO-[2,3-D]AZEPINE 95.00%
5MG
$ 496.62

Total 22 raw suppliers

Chemical Property of 5,6,7,8-Tetrahydro-4H-thieno[2,3-d]azepine

Chemical Property:

PSA：40.27000
LogP:1.76510
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:153.06122053
Heavy Atom Count:10
Complexity:116

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

5,6,7,8-TETRAHYDRO-4H-THIENO-[2,3-D]AZEPINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC2=C1C=CS2
Uses 5,6,7,8-Tetrahydro-4H-thieno[2,3-d]azepine is used as a reagent in the preparation of ethynylpyridines and related compounds as melanin-concentrating hormone receptor (MCH-1) antagonist for the treatment of metabolic disorders.

Technology Process of 5,6,7,8-Tetrahydro-4H-thieno[2,3-d]azepine

There total 14 articles about 5,6,7,8-Tetrahydro-4H-thieno[2,3-d]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873016-30-9
4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester

: 102997-01-3
5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine

Guidance literature:: With 1-(Trimethylsilyl)imidazole; In chloroform; at 70 ℃;

Reference yield:

: 102997-00-2
4-hydroxy-5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine

: 102997-01-3
5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine

Guidance literature:: With hydrogenchloride; tin(ll) chloride; In acetic acid; at 65 ℃; for 2h; Yield given;
DOI:10.1002/jhet.5570220416

Reference yield:

: 30433-91-1
[2-(2-thyenyl)ethyl]amine

: 102997-01-3
5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / K₂CO₃ / H₂O; CHCl₃ / 4 h / Ambient temperature

2: 95 percent / K₂CO₃ / dimethylformamide / 4 h / 90 °C

3: 90 percent / 2N aq. NaOH / ethanol / Ambient temperature; overnight

4: PCl₅ / 1,2-dichloro-ethane / 0.5 h / 60 °C

5: SnCl₂ / 1,2-dichloro-ethane / 2 h / -10 °C

6: 85 percent / NaBH₄ / ethanol / 1 h / Ambient temperature

7: pyrene, 0.1M tetrabutylammonium perchlorate / dimethylformamide / 0.5 h / cathode-mercury electrode, anode-graphite electrode; separation by membrane, ref. electrode-Ag/0.1M AgNO₃, appl. pot.=-2.52 V

8: SnCl₂*2H₂O, 12 N HCl / acetic acid / 2 h / 65 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; pyrene; phosphorus pentachloride; tetrabutylammonium perchlorate; potassium carbonate; tin(ll) chloride; In ethanol; chloroform; water; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570220416