(4-Methoxyphenyl)(2-phenyl-1H-indol-3-yl)methanone

Base Information

• Chemical Name: (4-Methoxyphenyl)(2-phenyl-1H-indol-3-yl)methanone
• CAS No.: 103056-99-1
• Molecular Formula: C22H17NO2
• Molecular Weight: 327.382
• DSSTox Substance ID: DTXSID70551953
• Nikkaji Number: J2.785.178I
• Wikidata: Q82431877
• Mol file: 103056-99-1.mol

Synonyms:103056-99-1;(4-Methoxyphenyl)(2-phenyl-1H-indol-3-yl)methanone;DTXSID70551953

Chemical Property of (4-Methoxyphenyl)(2-phenyl-1H-indol-3-yl)methanone

Chemical Property:

• PSA: 42.09000
• LogP: 5.07450
• XLogP3: 5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 327.125928785
• Heavy Atom Count: 25
• Complexity: 451

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=C(NC3=CC=CC=C32)C4=CC=CC=C4

Technology Process of (4-Methoxyphenyl)(2-phenyl-1H-indol-3-yl)methanone

There total 12 articles about (4-Methoxyphenyl)(2-phenyl-1H-indol-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C22H16BrNO → (4-methoxyphenyl)(2-phenyl-1H-indol-3-yl)methanone (103056-99-1)

Guidance literature:

With tetrabutylammomium bromide; water; palladium diacetate; caesium carbonate; triphenylphosphine; at 120 ℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/aoc.5513

Reference yield: 83.0%

N-phenylbenzamidine (1527-91-9) + 2-chloro-1-(4-methoxyphenyl)ethanone (2196-99-8) → (4-methoxyphenyl)(2-phenyl-1H-indol-3-yl)methanone (103056-99-1)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate; sodium hydrogencarbonate; In methanol; at 90 ℃; for 24h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03383

Reference yield: 76.0%

(Z)-1-(4-methoxyphenyl)-3-phenyl-3-(phenylamino)prop-2-en-1-one (75371-62-9) → (4-methoxyphenyl)(2-phenyl-1H-indol-3-yl)methanone (103056-99-1)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; lithium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 48h; Sealed tube;

DOI:10.1002/anie.200902440

upstream raw materials:

2-phenyl-indole

4-methoxy-benzoyl chloride

carbon monoxide

para-iodoanisole