Technology Process of Methanone,
[2-(3,4-dichlorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl]phenyl-
There total 10 articles about Methanone,
[2-(3,4-dichlorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl]phenyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
benzonitrile; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 71 percent / anhydrous sodium acetate, Br2 / acetic acid / 1.) 80 deg C, 6 h, 2.) 25 deg C, 16 h;
2: 1.) n-butyllithium / 1.) ether, hexane, -78 deg C, 15 min, 2.) THF, -65 deg C;
3: 84 percent / 48percent HBr / acetic acid / 0.25 h / 95 - 100 °C
4: 59 percent / H2 / W-2 Raney Nickel / ethanol; tetrahydrofuran / 6 h
5: 1.) t-butyllithium, / 1.) toluene, ether, pentan, -100 deg C, 20 min. 2.) -100 deg C;
With
n-butyllithium; hydrogen bromide; hydrogen; bromine; tert.-butyl lithium; sodium acetate;
W-2 Raney nickel;
In
tetrahydrofuran; ethanol; acetic acid;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-butyllithium / 1.) ether, hexane, -78 deg C, 15 min, 2.) THF, -65 deg C;
2: 84 percent / 48percent HBr / acetic acid / 0.25 h / 95 - 100 °C
3: 59 percent / H2 / W-2 Raney Nickel / ethanol; tetrahydrofuran / 6 h
4: 1.) t-butyllithium, / 1.) toluene, ether, pentan, -100 deg C, 20 min. 2.) -100 deg C;
With
n-butyllithium; hydrogen bromide; hydrogen; tert.-butyl lithium;
W-2 Raney nickel;
In
tetrahydrofuran; ethanol; acetic acid;
