(2-Hydroxymethyl-1,3-dihydroxy-2-propyl)amide of 4-phenylacetic acid

Base Information

• Chemical Name: (2-Hydroxymethyl-1,3-dihydroxy-2-propyl)amide of 4-phenylacetic acid
• CAS No.: 64205-65-8
• Molecular Formula: C₁₆H₂₄Cl₂N₂O₄
• Molecular Weight: 379.284

Synonyms:

Chemical Property of (2-Hydroxymethyl-1,3-dihydroxy-2-propyl)amide of 4-phenylacetic acid

Chemical Property:

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Technology Process of (2-Hydroxymethyl-1,3-dihydroxy-2-propyl)amide of 4-phenylacetic acid

There total 2 articles about (2-Hydroxymethyl-1,3-dihydroxy-2-propyl)amide of 4-phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

p-phenylacetyl chloride hydrochloride (53039-95-5) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → (2-Hydroxymethyl-1,3-dihydroxy-2-propyl)amide of 4-phenylacetic acid (64205-65-8)

Guidance literature:

In water; acetone; at -10 ℃; for 0.25h;

DOI:10.1007/BF00758456

Reference yield:

4-bis(2-chloroethyl)aminophenylacetic acid (10477-72-2) → (2-Hydroxymethyl-1,3-dihydroxy-2-propyl)amide of 4-phenylacetic acid (64205-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: 50 percent / H₂O; acetone / 0.25 h / -10 °C

With thionyl chloride; In water; acetone;

DOI:10.1007/BF00758456

Reference yield: 78.0%

(2-Hydroxymethyl-1,3-dihydroxy-2-propyl)amide of 4-phenylacetic acid (64205-65-8) + acetyl chloride (75-36-5) → (2-Acetoxymethyl-1,3-diacetoxy-2-propyl)amide of 4-phenylacetic acid (79567-53-6)

Guidance literature:

for 2h; Heating;

DOI:10.1007/BF00758456

upstream raw materials:

p-phenylacetyl chloride hydrochloride

2-amino-2-hydroxymethyl-1,3-propanediol

4-bis(2-chloroethyl)aminophenylacetic acid

Downstream raw materials:

(5-Hydroxymethyl-2,2-pentamethylene-1,3-dioxan-5-yl)amide of 4--phenylacetic acid

(2-Acetoxymethyl-1,3-diacetoxy-2-propyl)amide of 4-phenylacetic acid

(5-Hydroxymethyl-2,2-dimethyl-1,3-dioxan-5-yl)amide of 4-phenylacetic acid

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