1-[4-[3-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

Base Information

Chemical Name:1-[4-[3-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone
CAS No.:58113-48-7
Molecular Formula:C₃₀H₃₁F₂NO₃
Molecular Weight:491.578
Hs Code.:
ChEMBL ID:CHEMBL323560
DSSTox Substance ID:DTXSID101122652
Nikkaji Number:J460.495D

Synonyms:CHEMBL323560;SCHEMBL10562079;DTXSID101122652;58113-48-7;1-[4-[3-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

Suppliers and Price of 1-[4-[3-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-[4-[3-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

Chemical Property:

XLogP3:6.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:491.22720018
Heavy Atom Count:36
Complexity:694

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(=C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)CC2)OC

Technology Process of 1-[4-[3-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

There total 5 articles about 1-[4-[3-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 58113-48-7
1-[4-[3-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / pyridine / 2 h / Ambient temperature

2: diethyl ether; tetrahydrofuran / 12 h / Ambient temperature

3: phenol, 48percent aq. HBr / 7 h / Heating

4: K₂CO₃, KI / butan-1-ol / Heating

With pyridine; hydrogen bromide; potassium carbonate; potassium iodide; phenol; In tetrahydrofuran; diethyl ether; butan-1-ol;
DOI:10.1021/jm00114a009

Reference yield:

: 111627-26-0
1-(phenylsulfonyl)-4-piperidinecarboxylic acid ethyl ester

: 58113-48-7
1-[4-[3-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether; tetrahydrofuran / 12 h / Ambient temperature

2: phenol, 48percent aq. HBr / 7 h / Heating

3: K₂CO₃, KI / butan-1-ol / Heating

With hydrogen bromide; potassium carbonate; potassium iodide; phenol; In tetrahydrofuran; diethyl ether; butan-1-ol;
DOI:10.1021/jm00114a009

Reference yield:

: 111627-27-1
α,α-bis(4-fluorophenyl)-1-(phenylsulfonyl)-4-piperidinemethanol

: 58113-48-7
1-[4-[3-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: phenol, 48percent aq. HBr / 7 h / Heating

2: K₂CO₃, KI / butan-1-ol / Heating

With hydrogen bromide; potassium carbonate; potassium iodide; phenol; In butan-1-ol;
DOI:10.1021/jm00114a009