2-(6-(3,5-di-tert-butyl-2-(methoxymethoxy)phenyl)pyridin-2-yl)-N-(1-phenylethyl)aniline

Base Information

• Chemical Name: 2-(6-(3,5-di-tert-butyl-2-(methoxymethoxy)phenyl)pyridin-2-yl)-N-(1-phenylethyl)aniline
• CAS No.: 1383710-30-2
• Molecular Formula: C₃₅H₄₂N₂O₂
• Molecular Weight: 522.731
• Mol file: 1383710-30-2.mol

Synonyms:

Chemical Property of 2-(6-(3,5-di-tert-butyl-2-(methoxymethoxy)phenyl)pyridin-2-yl)-N-(1-phenylethyl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-(3,5-di-tert-butyl-2-(methoxymethoxy)phenyl)pyridin-2-yl)-N-(1-phenylethyl)aniline

There total 4 articles about 2-(6-(3,5-di-tert-butyl-2-(methoxymethoxy)phenyl)pyridin-2-yl)-N-(1-phenylethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-N-(1-phenylethyl)aniline (1019544-78-5) → 2-(6-(3,5-di-tert-butyl-2-(methoxymethoxy)phenyl)pyridin-2-yl)-N-(1-phenylethyl)aniline (1383710-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; triethylamine; CyJohnPhos / 1,4-dioxane / 1.5 h / 80 °C / Inert atmosphere

2: barium hydroxide octahydrate / 16 h / 90 °C / Inert atmosphere

With barium hydroxide octahydrate; palladium diacetate; triethylamine; CyJohnPhos; In 1,4-dioxane; 1: Suzuki coupling;

DOI:10.1039/c2cc32806b

Reference yield:

1-bromo-3,5-di-tert-butyl-2-(methoxymethoxy)benzene → 2-(6-(3,5-di-tert-butyl-2-(methoxymethoxy)phenyl)pyridin-2-yl)-N-(1-phenylethyl)aniline (1383710-30-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice

1.2: 2.5 h / -78 - 20 °C / Inert atmosphere

2.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 168 h / 20 - 115 °C / Inert atmosphere

3.1: barium hydroxide octahydrate / 16 h / 90 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; barium hydroxide octahydrate; In diethyl ether; hexane; toluene; 2.1: Suzuki coupling;

DOI:10.1039/c2cc32806b

Reference yield:

2-(3,5-di-tert-butyl-2-(methoxymethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1383710-31-3) → 2-(6-(3,5-di-tert-butyl-2-(methoxymethoxy)phenyl)pyridin-2-yl)-N-(1-phenylethyl)aniline (1383710-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 168 h / 20 - 115 °C / Inert atmosphere

2: barium hydroxide octahydrate / 16 h / 90 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate; In toluene; 1: Suzuki coupling;

DOI:10.1039/c2cc32806b

upstream raw materials:

2-bromo-N-(1-phenylethyl)aniline

2-bromo-6-(3,5-di-tert-butyl-2-(methoxymethoxy)phenyl)pyridine

2-(3,5-di-tert-butyl-2-(methoxymethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane