3-phenyl-5-(3,4,5,-tri-OCH₃-phenyl)-4,5-dihydro 1H-pyrazole-1-carbothioamide

Base Information

• Chemical Name: 3-phenyl-5-(3,4,5,-tri-OCH₃-phenyl)-4,5-dihydro 1H-pyrazole-1-carbothioamide
• CAS No.: 1370046-40-4
• Molecular Formula: C₁₉H₂₁N₃O₃S
• Molecular Weight: 371.46
• Mol file: 1370046-40-4.mol

Synonyms:

Chemical Property of 3-phenyl-5-(3,4,5,-tri-OCH₃-phenyl)-4,5-dihydro 1H-pyrazole-1-carbothioamide

Chemical Property:

• Boiling Point: 518.7±60.0 °C(Predicted)
• Density: 1.27±0.1 g/cm3(Predicted)

Purity/Quality:

98% min ^*data from raw suppliers

SSE15206 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-5-(3,4,5,-tri-OCH₃-phenyl)-4,5-dihydro 1H-pyrazole-1-carbothioamide

There total 3 articles about 3-phenyl-5-(3,4,5,-tri-OCH₃-phenyl)-4,5-dihydro 1H-pyrazole-1-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4,5-trimethoxychalcone (127034-55-3,60246-63-1) + thiosemicarbazide (79-19-6) → 3-phenyl-5-(3,4,5,-tri-OCH3-phenyl)-4,5-dihydro 1H-pyrazole-1-carbothioamide (1370046-40-4)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 8h; Reflux;

DOI:10.1080/00958972.2013.773318

Reference yield:

acetophenone (98-86-2) → 3-phenyl-5-(3,4,5,-tri-OCH3-phenyl)-4,5-dihydro 1H-pyrazole-1-carbothioamide (1370046-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 3 - 4 h / 25 °C

2: sodium hydroxide / ethanol; water / 8 h / Reflux

With sodium hydroxide; In ethanol; water;

DOI:10.1080/00958972.2013.773318

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → 3-phenyl-5-(3,4,5,-tri-OCH3-phenyl)-4,5-dihydro 1H-pyrazole-1-carbothioamide (1370046-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 3 - 4 h / 25 °C

2: sodium hydroxide / ethanol; water / 8 h / Reflux

With sodium hydroxide; In ethanol; water;

DOI:10.1080/00958972.2013.773318

upstream raw materials:

acetophenone

3,4,5-trimethoxychalcone

thiosemicarbazide

3,4,5-trimethoxy-benzaldehyde